Cyclooxygenase-2 as a therapeutic target against human breast cancer: A comprehensive review.

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Ankita Sahu, Khalid Raza, Dibyabhaba Pradhan, Arun Kumar Jain, Saurabh Verma
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引用次数: 4

Abstract

Cyclooxygenase-2 (COX-2) is a key aspect of the physiology and pathogenesis of various cancer types. Overexpression of this enzyme is responsible for the elevated prostaglandin production and characteristic feature of breast cancer. Inhibition of COX-2 derived prostanoids facilitates anti-inflammatory, analgesic, and antipyretic effects of non-steroid anti-inflammation drugs. The overexpression of COX-2 is associated with inflammation, pain, and fever. The present study provides the updated relevant literature describing the role of well-characterized isoforms of cyclooxygenase with particular emphasis on COX-2, mechanism of action, the effect of the drug, combinatorial drugs, and microarray-based differential expression analysis and network analysis. We have discussed the currently used combinatorial treatments and their challenges in breast cancer. This article is categorized under: Cancer > Computational Models Cancer > Molecular and Cellular Physiology.

Abstract Image

环氧化酶-2作为治疗人乳腺癌的靶点:综述
环氧合酶-2 (COX-2)是各种类型癌症生理和发病机制的关键方面。这种酶的过度表达是导致前列腺素产生升高和乳腺癌的特征。抑制COX-2衍生的前列腺素促进非类固醇抗炎药物的抗炎、镇痛和解热作用。COX-2的过表达与炎症、疼痛和发热有关。本研究提供了最新的相关文献,描述了环氧化酶同种异构体的作用,特别强调了COX-2,作用机制,药物作用,组合药物以及基于微阵列的差异表达分析和网络分析。我们已经讨论了目前使用的联合治疗方法及其在乳腺癌中的挑战。本文分类为:癌症>计算模型>分子和细胞生理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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