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Evaluating AlphaFold for Clinical Pharmacology and Pharmacogenetics: A Case-Study of Huntingtin Variants Linked to Huntington’s Disease

Pub Date : 2024-09-17 DOI: 10.1208/s12248-024-00969-9 Ajith Kumar Ethirajulu, Vineesh Sriramoju, Amruta Gajanan Bhat, Murali Ramanathan

Determining the Degree of Sulfo-tag Conjugation to AAV5 Vectors by LC-HRMS and Evaluating the Effects on Antibody Binding Affinity and Bridging Assay Sensitivity

Pub Date : 2024-09-16 DOI: 10.1208/s12248-024-00970-2 Yanshan Dai, Xinqun Wu, Xiaowei Sun, Daniel Cohen, Divakar Rajeswaran, Scott Robotham, Shannon Chilewski, Kun Yang, Graham Yearwood, Alexander Kozhich, Vibha Jawa

Planning Split-Apheresis Designs for Demonstrating Comparability of Cellular and Gene Therapy Products

Pub Date : 2024-09-16 DOI: 10.1208/s12248-024-00977-9 Richard Burdick, Jeff Hofer, Andrew Karl, Heath Rushing
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