发布求助
文献互助 智能选刊 最新文献

Classical Resolution for Atropisomerically Pure Intermediate

有机合成与工艺文献分享 2025-10-10 06:56
文章摘要
本文研究了通过经典手性拆分方法分离构象异构体1的可行性。背景是已获得rac-1的快速合成路线，研究目的是评估不同拆分剂对构象异构体的分离效果。实验发现(+)-DBTA能选择性拆分M-1异构体，形成三组分共晶溶剂化物，且(+)-DBTA浓度需超过200 mg/mL才能热力学优先结晶。研究结论表明提高(+)-DBTA浓度可提升M/P比例并抑制rac-1结晶，该工艺已成功应用于500公斤级生产，为合成KRAS G12C抑制剂sotorasib提供关键中间体。
Classical Resolution for Atropisomerically Pure Intermediate
查看文献： Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate
查看期刊： Organic Process Research & Development
阅读全文
本站注明稿件来源为其他媒体的文/图等稿件均为转载稿，本站转载出于非商业性的教育和科研之目的，并不意味着赞同其观点或证实其内容的真实性。如转载稿涉及版权等问题，请作者速来电或来函联系。
推荐文献
ACS Applied Polymer Materials ACS Applied Polymer Materials
Issue Editorial Masthead
DOI: 10.1021/apv007i019_1992570 Pub Date : 2025-10-10
IF 4.7 2区 化学 Q2 ACS Applied Polymer Materials
Accounts of Chemical Research Accounts of Chemical Research
On Free Energy Calculations in Drug Discovery
DOI: 10.1021/acs.accounts.5c00465 Pub Date : 2025-10-10
IF 18.3 1区 化学 Q1 Accounts of Chemical Research
Organic Process Research & Development Organic Process Research & Development
A Short Route to Midazolam via Michael Addition to a Nitroolefin
DOI: 10.1021/acs.oprd.5c00320 Pub Date : 2025-10-14
IF 3.4 3区 化学 Q2 Organic Process Research & Development
有机合成与工艺文献分享
Development of Adagrasib’s Commercial Manufacturing Route (1)
Development of Adagrasib’s Commercial Manufacturing Route (1). 2025-10-16
Quench-Crystallization Operation in Drug Substance Manufacturing
Quench-Crystallization Operation in Drug Substance Manufacturing. 2025-10-15
Suzuki Coupling: What a Difference a Base Makes
Suzuki Coupling: What a Difference a Base Makes. 2025-10-14
Leveraging a High-Temperature Thermal Racemization
Leveraging a High-Temperature Thermal Racemization. 2025-10-12
Synthesis of Substituted Pyridines via (3+3) Cycloaddition
Synthesis of Substituted Pyridines via (3+3) Cycloaddition. 2025-10-08
最新文章
Development of Adagrasib’s Commercial Manufacturing Route (1)
Development of Adagrasib’s Commercial Manufacturing Route (1) 2025-10-16
Quench-Crystallization Operation in Drug Substance Manufacturing
Quench-Crystallization Operation in Drug Substance Manufacturing 2025-10-15
Suzuki Coupling: What a Difference a Base Makes
Suzuki Coupling: What a Difference a Base Makes 2025-10-14
Leveraging a High-Temperature Thermal Racemization
Leveraging a High-Temperature Thermal Racemization 2025-10-12
热门类别
综合性期刊 物理 法学 地球科学 历史学
相关文章
ILIS 2025 | 现场对接会 Networking for 中国好仪器 & 国际实验室专家 西工大李金山教授团队连发4篇《Acta Materialia 》！AI for Materials Classical Resolution for Atropisomerically Pure Intermediate 10月16日 · 免费线上参会 | AI for Discovery and Research Automation AI for Polymers | OpenPoly：面向基准测试与多性质集成的高分子数据库
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信