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Pd(II)-catalyzed One-Pot Desilylation

有机合成与工艺文献分享 2025-09-04 08:13
文章摘要
背景：有机合成中脱硅基化反应是常见步骤，传统方法需使用酸/碱，但可能对酸敏感性底物造成影响。研究目的：开发无需外加酸的温和脱硅基化方法，利用PdCl2(MeCN)2催化剂实现TBS保护基的高效脱除，并解决生产规模中的重现性和副产物残留问题。结论：成功建立Pd(II)催化的脱硅基化工艺，通过添加适量水提高反应效率，实现公斤级规模生产，且反应后的THF流可直接用于后续甲基铜酸盐加成，无需纯化。
Pd(II)-catalyzed One-Pot Desilylation
查看文献： A Scalable Synthesis of (R,R)-2,6-Dimethyldihydro-2H-pyran-4(3H)-one
查看期刊： Organic Process Research & Development
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