发布求助
文献互助 智能选刊 最新文献

Cost Driving Development of New Catalytic Asymmetric Routes (2)

有机合成与工艺文献分享 2025-07-03 08:51
文章摘要
本文探讨了新型不对称催化路径的开发，重点研究了铜催化和手性Bro̷nsted碱催化在控制不对称Michael加成中的应用。研究目的是通过降低催化剂负载量和优化反应条件（如温度和浓度）来提高反应的成本效益。实验证明，使用2 mol%的手性催化剂11在7克规模的实验中，成功实现了66%的产率。此外，还研究了不对称双功能氢键供体（HBD）催化剂的应用，并在25克规模的实验中观察到副产物减少。最终，研究成功合成了关键起始材料3。
Cost Driving Development of New Catalytic Asymmetric Routes (2)
查看文献： Development of New Catalytic Asymmetric Routes toward a Cost-Driving Building Block of Nirmatrelvir
查看期刊： Organic Process Research & Development
阅读全文
本站注明稿件来源为其他媒体的文/图等稿件均为转载稿，本站转载出于非商业性的教育和科研之目的，并不意味着赞同其观点或证实其内容的真实性。如转载稿涉及版权等问题，请作者速来电或来函联系。
推荐文献
Organic Process Research & Development Organic Process Research & Development
Polymorph and Salt/Cocrystal Screening to Identify a Suitable Physical Form for an LPAR1 Antagonist, GS-2278
DOI: 10.1021/acs.oprd.5c00065 Pub Date : 2025-06-25
IF 3.4 3区 化学 Q2 Organic Process Research & Development
ACS Applied Polymer Materials ACS Applied Polymer Materials
Pub Date : 2025-06-27
IF 4.4 2区 化学 Q2 ACS Applied Polymer Materials
Accounts of Chemical Research Accounts of Chemical Research
Direct Reductive Transformation of Amides: From Methodology Development to Applications in Total Synthesis.
DOI: 10.1021/acs.accounts.5c00366 Pub Date : 2025-07-03
IF 18.3 1区 化学 Q1 Accounts of Chemical Research
有机合成与工艺文献分享
A Mild and Efficient Process for Ir-Catalyzed N‑Alkylation
A Mild and Efficient Process for Ir-Catalyzed N‑Alkylation. 2025-07-03
Cost Driving Development of New Catalytic Asymmetric Routes (1)
Cost Driving Development of New Catalytic Asymmetric Routes (1). 2025-07-02
Process Development for a Tetrazole-Based Agonist Intermediate
Process Development for a Tetrazole-Based Agonist Intermediate. 2025-07-01
THETA as an Efficient Cu-Binding Ligand for “Click” Reaction
THETA as an Efficient Cu-Binding Ligand for “Click” Reaction. 2025-06-26
Commercial Route Development Toward PF-07265807 (4)
Commercial Route Development Toward PF-07265807 (4). 2025-06-25
最新文章
A Mild and Efficient Process for Ir-Catalyzed N‑Alkylation
A Mild and Efficient Process for Ir-Catalyzed N‑Alkylation 2025-07-03
Cost Driving Development of New Catalytic Asymmetric Routes (2)
Cost Driving Development of New Catalytic Asymmetric Routes (2) 2025-07-03
Cost Driving Development of New Catalytic Asymmetric Routes (1)
Cost Driving Development of New Catalytic Asymmetric Routes (1) 2025-07-02
Process Development for a Tetrazole-Based Agonist Intermediate
Process Development for a Tetrazole-Based Agonist Intermediate 2025-07-01
热门类别
综合性期刊 物理 法学 地球科学 历史学
相关文章
期刊 |《预防青少年犯罪研究》2025年第2期要目 每周5份黑巧克力，2型糖尿病风险降 21%！BMJ证实：牛奶巧克力无此效，还可能致体重增加 【第1卷第2期】SmartBot第2期正式上线！ 《人权研究》2025年第2期要目｜法大人权院 《澳门法学》2025年第2期｜澳门回归20周年纪念号要目
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信