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Practical Synthesis of Chiral 3‑(Hydroxyiminomethyl)adipic Acid

有机合成与工艺文献分享 2025-04-14 08:56

文章摘要

本文研究了手性3-(羟基亚氨基甲基)己二酸及其等价物的三种合成方法。研究背景涉及不对称烷基化和曼尼希反应的应用，旨在寻找适合工业生产的有效合成路径。通过实验发现，使用不同量的(S)-1-苯乙胺可以控制产物的构型，但部分反应条件下会出现外消旋化问题。最终研究成功开发出一种通过分批加入固体的方法，以96%的对映体过量获得目标产物(S)-4a。结论指出，银基催化体系在温和条件下能有效促进芳香羧酸的选择性脱羧反应。

Practical Synthesis of Chiral 3‑(Hydroxyiminomethyl)adipic Acid

查看文献： Practical Synthesis of Chiral 3-(Hydroxyiminomethyl)adipic Acid, a Key Intermediate of the ROR-γ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution
查看期刊： Organic Process Research & Development

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