发布求助

文献互助智能选刊最新文献

Efficient Manufacturing Process for GDC-9545

有机合成与工艺文献分享 2024-12-25 07:20

文章摘要

本文介绍了GDC-9545的高效制造工艺，重点在于通过Pictet−Spengler反应构建关键中间体。文章探讨了多种合成tryptamine的方法，并最终选择了Wenker氮丙啶合成法，成功展示了从二甲酯24开始的100公斤规模的三步缩合工艺。研究还提出了替代工艺以解决原有工艺在规模化生产中的不足，特别是通过C−N偶联反应优化了氨基酸氮杂环丁烷中间体的构建。

Efficient Manufacturing Process for GDC-9545

查看文献： Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet–Spengler Condensation
查看期刊： Organic Process Research & Development

本站注明稿件来源为其他媒体的文/图等稿件均为转载稿，本站转载出于非商业性的教育和科研之目的，并不意味着赞同其观点或证实其内容的真实性。如转载稿涉及版权等问题，请作者速来电或来函联系。

推荐文献

ACS Applied Polymer Materials

ACS Applied Polymer Materials

Long-term Outcomes of Persistent Postoperative Opioid Use: A Retrospective Cohort Study.

DOI: 10.1097/SLA.0000000000005372 Pub Date : 2025-01-01 Date: 2024/12/16 0:00:00

IF 4.4 2区化学 Q2 ACS Applied Polymer Materials

Accounts of Chemical Research

Accounts of Chemical Research

The Moderating Roles of Resilience and Coping Strategy on Well-Being of Victimized Forensic Workers.

DOI: 10.1177/0306624X221124834 Pub Date : 2025-01-01 Date: 2022/9/30 0:00:00

IF 16.4 1区化学 Q1 Accounts of Chemical Research

Organic Process Research & Development

Organic Process Research & Development

Impurity Control Strategy of TMS-Triol in the Manufacture Development of Islatravir

DOI: 10.1021/acs.oprd.4c00368 Pub Date : 2024-12-22

IF 3.4 3区化学 Q2 Organic Process Research & Development

有机合成与工艺文献分享

First-Generation Asymmetric Synthesis of Giredestrant

First-Generation Asymmetric Synthesis of Giredestrant. 2024-12-23

Practical Synthesis of N-Unprotected β-Amino Esters

Practical Synthesis of N-Unprotected β-Amino Esters. 2024-12-23

Direct Asymmetric Reductive Amination

Direct Asymmetric Reductive Amination. 2024-12-22

Direct Asymmetric Reductive Amination with Ammonia

Direct Asymmetric Reductive Amination with Ammonia. 2024-12-20

Asymmetric Reductive Amination of Ketones with Ammonia and H2

Asymmetric Reductive Amination of Ketones with Ammonia and H2. 2024-12-20

最新文章

Efficient Manufacturing Process for GDC-9545

Efficient Manufacturing Process for GDC-9545 23小时前

First-Generation Asymmetric Synthesis of Giredestrant

First-Generation Asymmetric Synthesis of Giredestrant 2024-12-23

Practical Synthesis of N-Unprotected β-Amino Esters

Practical Synthesis of N-Unprotected β-Amino Esters 2024-12-23

Direct Asymmetric Reductive Amination

Direct Asymmetric Reductive Amination 2024-12-22

热门类别

综合性期刊物理法学地球科学历史学

相关文章

Efficient Manufacturing Process for GDC-9545 【Call for Chapters】Springer Book: 面向星地融合网络的人工智能 AI for Science 是科学的未来，NVIDIA 正加速它的到来 Nature子刊：AI for Science机器学习揭示电催化剂多位点协同效应,开发高能量锂电池 Development of a Scalable Alkylation for BMT-773752

联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1

京公网安备 11010802042870号

Book学术文献互助

Book学术文献互助群
群号：481959085

Book学术官方微信