睾酮与外周动脉疾病。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Aleš Blinc, Gerit Holger Schernthaner, Pavel Poredoš, Panagiotis Anagnostis, Mojca Jensterle, Katica Bajuk Studen, Pier Luigi Antignani, Dimitri P Mikhailidis, Mišo Šabović
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引用次数: 0

摘要

男性的睾丸激素水平在成年早期开始下降,每年下降1-2%。男性睾酮水平低与肥胖、代谢综合征、糖尿病、血脂异常、高血压和心血管疾病死亡率增加有关。然而,男性睾酮水平及其与外周动脉疾病(PAD)关系的观察性研究得出了不同的结果;只有一些队列显示出与游离睾酮水平低的明显关联。这种差异部分可能是由于估计游离睾酮的方法问题,但也可能是睾酮对血管壁和代谢的不同影响。睾酮在改善血糖控制、抗肥胖和诱导血管舒张的同时,还能刺激血小板聚集,增加红细胞压积。晚期前列腺癌的雄激素剥夺治疗可能与心血管风险升高有关,滥用雄激素以提高表现也是如此。另一方面,明智地治疗男性性腺功能减退症或治疗跨性别男性的睾酮似乎是安全的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Testosterone and Peripheral Arterial Disease.

Testosterone levels in men begin declining in the early years of adulthood, with a 1-2% reduction/year. Low testosterone levels in men are associated with obesity, metabolic syndrome, diabetes mellitus, dyslipidaemia, hypertension and increased cardiovascular mortality. However, observational studies of testosterone levels in males and their relationship with peripheral arterial disease (PAD) have yielded mixed results; only some cohorts show a clear association with low free testosterone levels. This discrepancy may, in part, be due to methodological issues with estimating free testosterone but also to different effects of testosterone on the vessel wall and metabolism. While testosterone improves glycaemic control, has anti-obesity effects and induces vasodilation, it also stimulates platelet aggregation and increases the haematocrit. Androgen deprivation treatment for advanced prostate cancer may be associated with elevated cardiovascular risk, as is testosterone abuse for performance enhancement. On the other hand, judicious treatment of male hypogonadism or testosterone treatment of trans-men appears to be safe.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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