对患有镰状细胞病的老年青少年和成年人进行非消融性造血干细胞移植的纵向神经认知影响:描述以及与同胞捐献者的比较。

IF 1.7 3区 心理学 Q4 NEUROSCIENCES
Neuropsychological Rehabilitation Pub Date : 2024-08-01 Epub Date: 2023-08-04 DOI:10.1080/09602011.2023.2238948
Emily J Carlson, Nour Al Ghriwati, Pam Wolters, Mary Anne Tamula, John Tisdale, Courtney Fitzhugh, Matt Hsieh, Staci Martin
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引用次数: 0

摘要

镰状细胞病(SCD)与神经认知障碍的风险增加有关。然而,非消融性造血干细胞移植(HSCT)后功能是否会发生变化仍不清楚。本研究旨在考察SCD患者移植前到移植后的神经心理功能变化,并将患者与兄弟姐妹进行比较。成人SCD患者(n = 47;Mage = 31.8 ± 8.9)及其兄弟姐妹干细胞捐献者(n = 22;Mage = 30.5 ± 9.2)参加了非髓鞘消融HCST方案,在基线和移植后12个月完成了认知和患者报告结果评估。路径分析用于评估移植前变量和兄弟姐妹/患者群体状况与移植后功能之间的关联。患者在两个时间点的平均认知评分均为平均值。从基线到随访期间,患者的处理速度和躯体不适有所改善。基线成绩可预测各认知变量的随访成绩;患者/兄弟姐妹状况可预测某些处理速度测量的随访成绩。结果表明,SCD 患者的处理速度比兄弟姐妹慢。从造血干细胞移植前到移植后,患者和兄弟姐妹的处理速度都有所提高,而且在某些指标上,患者的改善幅度更大。因此,造血干细胞移植可能会提高患者的处理速度,但还需要进一步证实。研究结果提供了令人鼓舞的证据,表明SCD患者的神经认知功能在非骨髓移植造血干细胞移植术前至术后12个月期间保持稳定,不会产生有害影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Longitudinal neurocognitive effects of nonmyeloablative hematopoietic stem cell transplant among older adolescents and adults with sickle cell disease: A description and comparison with sibling donors.

Sickle cell disease (SCD) is associated with increased risk of neurocognitive deficits. However, whether functioning changes following nonmyeloablative hematopoietic stem cell transplant (HSCT) remains unclear. This study aimed to examine changes in neuropsychological functioning pre- to post-transplant among patients with SCD and compare patients and siblings. Adults with SCD (n = 47; Mage = 31.8 ± 8.9) and their sibling stem cell donors (n = 22; Mage = 30.5± 9.2) enrolled on a nonmyeloablative HCST protocol completed cognitive and patient-reported outcome assessments at baseline and 12 months post-transplant. Path analyses were used to assess associations between pre-transplant variables and sibling/patient group status and post-transplant function. Mean patient cognitive scores were average at both timepoints. Patient processing speed and somatic complaints improved from baseline to follow-up. Baseline performance predicted follow-up performance across cognitive variables; patient/sibling status predicted follow-up performance on some processing speed measures. Results suggest that patients with SCD demonstrate slower processing speed than siblings. Processing speed increased pre- to post-HSCT among patients and siblings, and on some measures patients demonstrated greater improvement. Thus, HSCT may improve processing speed in patients, although further confirmation is needed. Findings provide promising evidence that neurocognitive functioning remains stable without detrimental effects from pre- to 12-months post nonmyeloablative HSCT in individuals with SCD.

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来源期刊
Neuropsychological Rehabilitation
Neuropsychological Rehabilitation 医学-神经科学
CiteScore
6.30
自引率
7.40%
发文量
78
审稿时长
>12 weeks
期刊介绍: Neuropsychological Rehabilitation publishes human experimental and clinical research related to rehabilitation, recovery of function, and brain plasticity. The journal is aimed at clinicians who wish to inform their practice in the light of the latest scientific research; at researchers in neurorehabilitation; and finally at researchers in cognitive neuroscience and related fields interested in the mechanisms of recovery and rehabilitation. Papers on neuropsychological assessment will be considered, and special topic reviews (2500-5000 words) addressing specific key questions in rehabilitation, recovery and brain plasticity will also be welcomed. The latter will enter a fast-track refereeing process.
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