ARID5B、IKZF1、GATA3、CEBPE 和 CDKN2A 基因多态性与儿童急性淋巴细胞白血病的易感性。

IF 1.2 4区 医学 Q4 HEMATOLOGY
Pediatric Hematology and Oncology Pub Date : 2024-01-01 Epub Date: 2023-08-14 DOI:10.1080/08880018.2023.2234946
Nermeen R Al-Zayan, Mohammed J Ashour, Hadeer N Abuwarda, Fadel A Sharif
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引用次数: 0

摘要

急性淋巴细胞白血病(ALL)是最常见的儿科癌症。在不同人群中,包括 ARID5B (rs10821936 T/C)、IKZF1 (rs4132601 T/G)、GATA3 (rs3824662 G/T)、CEBPE (rs2239633 G/A) 和 CDKN2A (rs3731217 A/C)在内的种系单核苷酸多态性(SNPs)与小儿 ALL 有关联。迄今为止,还没有研究检测过这些 SNP 与加沙地带小儿 ALL 之间的关系。因此,我们调查了这些多态性与巴勒斯坦这一地区儿童 ALL 发生率之间的关系。这项病例对照研究招募了 100 名健康对照者和 78 名 ALL 患者。采用等位基因特异性 PCR(AS-PCR)技术进行 SNPs 基因分型。在分析基因与基因之间的相互作用时,采用了相关的统计检验和多因素降维(MDR)方法。在ALL患者中,ARID5B rs10821936 T/C(p = 0.007)和IKZF1 rs4132601 T/G(p = 0.045)的小等位基因显著较高。GATA3 rs3824662 G/T 的同源(TT)基因型(p = 0.038)、ARID5B rs10821936 T/C 的同源(CC)基因型(p = 0.在加沙地带的一个患者队列中,ARID5B rs10821936 T/C、IKZF1 rs4132601 T/G、GATA3 rs3824662 G/T 和 CDKN2A rs3731217 A/C 的多态性(AC 和 CC)基因型与小儿 ALL 的风险增加有关。为了证实这些发现并检验这些SNPs在预后和治疗敏感性方面的价值,还需要进行样本量更大的进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ARID5B, IKZF1, GATA3, CEBPE, and CDKN2A germline polymorphisms and predisposition to childhood acute lymphoblastic leukemia.

Acute lymphoblastic leukemia (ALL) is the most frequent type of pediatric cancer. Germline single nucleotide polymorphisms (SNPs), including ARID5B (rs10821936 T/C), IKZF1 (rs4132601 T/G), GATA3 (rs3824662 G/T), CEBPE (rs2239633 G/A), and CDKN2A (rs3731217 A/C) have been linked to pediatric ALL in different populations. Hitherto, no previous studies have tested the relationship between these SNPs and pediatric ALL in Gaza strip. Therefore, we investigated the association between these polymorphisms and the occurrence of childhood ALL in this part of Palestine. This case-control study recruited 100 healthy controls and 78 ALL patients. Allele-specific PCR (AS-PCR) technique was used for SNPs genotyping. Relevant statistical tests were used and the multifactor dimensionality reduction (MDR) approach was applied in the analysis of gene-gene interactions. Minor alleles of ARID5B rs10821936 T/C (p = 0.007) and IKZF1 rs4132601 T/G (p = 0.045) were significantly higher in ALL patients. The homozygous (TT) genotype of GATA3 rs3824662 G/T (p = 0.038), (CC) of ARID5B rs10821936 T/C (p = 0.008), and (AC and CC) genotypes of CDKN2A rs3731217 A/C (p < 0.0001) were significantly higher in ALL cases. On MDR analysis, the best model for ALL risk was the five-factor model combination of the examined SNPs (CVC = 10/10; TBA = 0.632; p < 0.0001). This work demonstrates the association of ARID5B rs10821936 T/C, IKZF1 rs4132601 T/G, GATA3 rs3824662 G/T, and CDKN2A rs3731217 A/C polymorphisms with increased risk of pediatric ALL among a patient cohort from Gaza Strip. Further studies with a larger sample size are needed in order to confirm these findings and test the value of these SNPs in prognosis and treatment sensitivity.

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来源期刊
CiteScore
2.60
自引率
5.90%
发文量
71
审稿时长
6-12 weeks
期刊介绍: PHO: Pediatric Hematology and Oncology covers all aspects of research and patient management within the area of blood disorders and malignant diseases of childhood. Our goal is to make PHO: Pediatric Hematology and Oncology the premier journal for the international community of clinicians and scientists who together aim to define optimal therapeutic strategies for children and young adults with cancer and blood disorders. The journal supports articles that address research in diverse clinical settings, exceptional case studies/series that add novel insights into pathogenesis and/or clinical care, and reviews highlighting discoveries and challenges emerging from consortia and conferences. Clinical studies as well as basic and translational research reports regarding cancer pathogenesis, genetics, molecular diagnostics, pharmacology, stem cells, molecular targeting, cellular and immune therapies and transplantation are of interest. Papers with a focus on supportive care, late effects and on related ethical, legal, psychological, social, cultural, or historical aspects of these fields are also appreciated. Reviews on important developments in the field are welcome. Articles from scientists and clinicians across the international community of Pediatric Hematology and Oncology are considered for publication. The journal is not dependent on or connected with any organization or society. All submissions undergo rigorous peer review prior to publication. Our Editorial Board includes experts in Pediatric Hematology and Oncology representing a wide range of academic and geographic diversity.
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