年龄和头部位置对使用粘膜雾化装置的人鼻内气道三维模型中总气溶胶沉积和区域气溶胶沉积的影响。

IF 2 4区 医学 Q3 RESPIRATORY SYSTEM
Jana S Kesavan, Kristina Kuypers, Douglas R Sommerville, Keith Sedberry, Beth L Laube
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引用次数: 0

摘要

背景:本研究考察了年龄和头部位置对粘膜雾化装置(MAD™)在18岁、5岁和2岁人类鼻内气道三维(3D)模型中释放的气溶胶总量和区域沉积的影响。模型由前鼻和鼻腔四部分组成,鼻腔水平分为上、中、下三分之一。方法:分别采用仰卧位、仰卧位头部后仰45°(supine45)、坐位头部后仰45°(sitting45)进行6次测试。在静态气流中,MAD将生理盐水/荧光素气溶胶送入模型鼻孔。使用荧光计测试模型片的荧光,并以相对于参考片的每片荧光百分比计算沉积。计算总沉积量(共4块)和区域沉积量(分别为4块)。结果:年龄和头部位置对总沉积量影响不大。相比之下,2岁大的模型与两种年龄较大的模型相比,仰卧的上、中三分之一45和坐着的下三分之一45的沉积有显著差异。此外,与其他位置相比,在每个模型中,某些头部位置显著增加了上、中、下三分之一的沉积。上肢沉积在仰卧45(18岁)和仰卧45(5岁)显著大于坐姿45(18岁)和仰卧45(5岁)。与坐位45相比,仰卧位和仰卧位45的中间沉积显著增加(2岁)。与仰卧45相比,坐姿45的低沉积量显著增加(18岁);仰卧和坐位45,与仰卧45(5岁)比较;与仰卧和仰卧(2岁)相比。结论:在这些三维模型中,年龄和头部位置显著影响MAD传递的气溶胶的区域沉积。这样的模型可能用于研究儿童和成人雾化药物靶向鼻内区域的其他方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Age and Head Position on Total and Regional Aerosol Deposition in Three-Dimensional Models of Human Intranasal Airways Using a Mucosal Atomization Device.

Background: This study examined the effect of age and head position on total and regional deposition of aerosol delivered by a mucosal atomization device (MAD™) in three-dimensional (3D) models of the intranasal airways of an 18-, 5-, and 2-year-old human. Models consisted of four pieces: anterior nose and nasal cavity that was divided horizontally into upper, middle, and lower thirds. Methods: Models were tested six times at supine, supine with head backward at 45° (supine45), and sitting with head backward at 45° (sitting45). The MAD delivered saline/fluorescein aerosol into model nostrils, during static airflow. Model pieces were tested for fluorescence using a fluorometer, and deposition calculated as percent fluorescence per piece relative to its reference. Total deposition (four pieces combined) and regional deposition (four pieces separately) were calculated. Results: Age and head position had little effect on total deposition. In contrast, deposition in the upper and middle third supine45 and in the lower third sitting45 was significantly different in the 2-year-old model, compared with the two older models. In addition, some head positions significantly increased deposition in the upper, middle, and lower thirds within each model, compared with other positions. Upper deposition was significantly greater at supine45, compared with sitting45 (18-year-old) and supine45, compared with supine and sitting45 (5-year-old). Middle deposition was significantly greater at supine and supine45, compared with sitting45 (2-year-old). Lower deposition was significantly greater at sitting45, compared with supine45 (18-year-old); supine and sitting45, compared with supine45 (5-year-old); and sitting45, compared with supine45 and supine (2-year-old). Conclusions: Age and head position significantly affected regional deposition of aerosol delivered by the MAD in these 3D models. Such models might be used to study other methods for targeting intranasal regions with aerosolized medications in children and adults.

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来源期刊
CiteScore
6.70
自引率
2.90%
发文量
34
审稿时长
>12 weeks
期刊介绍: Journal of Aerosol Medicine and Pulmonary Drug Delivery is the only peer-reviewed journal delivering innovative, authoritative coverage of the health effects of inhaled aerosols and delivery of drugs through the pulmonary system. The Journal is a forum for leading experts, addressing novel topics such as aerosolized chemotherapy, aerosolized vaccines, methods to determine toxicities, and delivery of aerosolized drugs in the intubated patient. Journal of Aerosol Medicine and Pulmonary Drug Delivery coverage includes: Pulmonary drug delivery Airway reactivity and asthma treatment Inhalation of particles and gases in the respiratory tract Toxic effects of inhaled agents Aerosols as tools for studying basic physiologic phenomena.
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