视网膜微血管复杂性作为生物年龄的假定生物标志物:一项初步研究。

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY
Biogerontology Pub Date : 2023-12-01 Epub Date: 2023-08-12 DOI:10.1007/s10522-023-10057-8
Natasa Popovic, Maša Ždralević, Stela Vujosevic, Miroslav Radunović, Antoaneta Adžić Zečević, Isidora Rovčanin Dragović, Batrić Vukčević, Tomo Popovic, Ljiljana Radulović, Tijana Vuković, Jevto Eraković, Ranko Lazović, Miodrag Radunović
{"title":"视网膜微血管复杂性作为生物年龄的假定生物标志物:一项初步研究。","authors":"Natasa Popovic, Maša Ždralević, Stela Vujosevic, Miroslav Radunović, Antoaneta Adžić Zečević, Isidora Rovčanin Dragović, Batrić Vukčević, Tomo Popovic, Ljiljana Radulović, Tijana Vuković, Jevto Eraković, Ranko Lazović, Miodrag Radunović","doi":"10.1007/s10522-023-10057-8","DOIUrl":null,"url":null,"abstract":"<p><p>Physiological changes associated with aging increase the risk for the development of age-related diseases. This increase is non-specific to the type of age-related disease, although each disease develops through a unique pathophysiologic mechanism. People who age at a faster rate develop age-related diseases earlier in their life. They have an older \"biological age\" compared to their \"chronological age\". Early detection of individuals with accelerated aging would allow timely intervention to postpone the onset of age-related diseases. This would increase their life expectancy and their length of good quality life. The goal of this study was to investigate whether retinal microvascular complexity could be used as a biomarker of biological age. Retinal images of 68 participants ages ranging from 19 to 82 years were collected in an observational cross-sectional study. Twenty of the old participants had age-related diseases such as hypertension, type 2 diabetes, and/or Alzheimer's dementia. The rest of the participants were healthy. Retinal images were captured by a hand-held, non-mydriatic fundus camera and quantification of the microvascular complexity was performed by using Sholl's, box-counting fractal, and lacunarity analysis. In the healthy subjects, increasing chronological age was associated with lower retinal microvascular complexity measured by Sholl's analysis. Decreased box-counting fractal dimension was present in old patients, and this decrease was 2.1 times faster in participants who had age-related diseases (p = 0.047). Retinal microvascular complexity could be a promising new biomarker of biological age. The data from this study is the first of this kind collected in Montenegro. It is freely available for use.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Retinal microvascular complexity as a putative biomarker of biological age: a pilot study.\",\"authors\":\"Natasa Popovic, Maša Ždralević, Stela Vujosevic, Miroslav Radunović, Antoaneta Adžić Zečević, Isidora Rovčanin Dragović, Batrić Vukčević, Tomo Popovic, Ljiljana Radulović, Tijana Vuković, Jevto Eraković, Ranko Lazović, Miodrag Radunović\",\"doi\":\"10.1007/s10522-023-10057-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Physiological changes associated with aging increase the risk for the development of age-related diseases. This increase is non-specific to the type of age-related disease, although each disease develops through a unique pathophysiologic mechanism. People who age at a faster rate develop age-related diseases earlier in their life. They have an older \\\"biological age\\\" compared to their \\\"chronological age\\\". Early detection of individuals with accelerated aging would allow timely intervention to postpone the onset of age-related diseases. This would increase their life expectancy and their length of good quality life. The goal of this study was to investigate whether retinal microvascular complexity could be used as a biomarker of biological age. Retinal images of 68 participants ages ranging from 19 to 82 years were collected in an observational cross-sectional study. Twenty of the old participants had age-related diseases such as hypertension, type 2 diabetes, and/or Alzheimer's dementia. The rest of the participants were healthy. Retinal images were captured by a hand-held, non-mydriatic fundus camera and quantification of the microvascular complexity was performed by using Sholl's, box-counting fractal, and lacunarity analysis. In the healthy subjects, increasing chronological age was associated with lower retinal microvascular complexity measured by Sholl's analysis. Decreased box-counting fractal dimension was present in old patients, and this decrease was 2.1 times faster in participants who had age-related diseases (p = 0.047). Retinal microvascular complexity could be a promising new biomarker of biological age. The data from this study is the first of this kind collected in Montenegro. It is freely available for use.</p>\",\"PeriodicalId\":8909,\"journal\":{\"name\":\"Biogerontology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biogerontology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10522-023-10057-8\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/8/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biogerontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10522-023-10057-8","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/12 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

与衰老相关的生理变化会增加患老年性疾病的风险。这种增加对与年龄相关的疾病类型是非特异性的,尽管每种疾病都通过独特的病理生理机制发展。衰老速度较快的人会在生命早期患上与年龄相关的疾病。与他们的“实际年龄”相比,他们的“生理年龄”更大。早期发现衰老加速的个体可以及时进行干预,推迟与年龄相关的疾病的发作。这将延长他们的预期寿命和高质量生活的时间。本研究的目的是研究视网膜微血管复杂性是否可以作为生物年龄的生物标志物。在一项观察性横断面研究中,收集了68名年龄从19岁到82岁的参与者的视网膜图像。20名老年参与者患有与年龄相关的疾病,如高血压、2型糖尿病和/或阿尔茨海默氏症。其余的参与者都很健康。用手持式非散瞳眼底相机拍摄视网膜图像,并使用Sholl’s、盒计数分形和腔隙性分析对微血管复杂性进行量化。在健康受试者中,Sholl分析显示,年龄增长与视网膜微血管复杂性降低有关。在老年患者中,盒计数分形维数降低,而在患有年龄相关疾病的参与者中,这种下降速度快2.1倍(p = 0.047)。视网膜微血管复杂性可能是一种很有前途的生物年龄新生物标志物。这项研究的数据是黑山首次收集到此类数据。它可以免费使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Retinal microvascular complexity as a putative biomarker of biological age: a pilot study.

Retinal microvascular complexity as a putative biomarker of biological age: a pilot study.

Physiological changes associated with aging increase the risk for the development of age-related diseases. This increase is non-specific to the type of age-related disease, although each disease develops through a unique pathophysiologic mechanism. People who age at a faster rate develop age-related diseases earlier in their life. They have an older "biological age" compared to their "chronological age". Early detection of individuals with accelerated aging would allow timely intervention to postpone the onset of age-related diseases. This would increase their life expectancy and their length of good quality life. The goal of this study was to investigate whether retinal microvascular complexity could be used as a biomarker of biological age. Retinal images of 68 participants ages ranging from 19 to 82 years were collected in an observational cross-sectional study. Twenty of the old participants had age-related diseases such as hypertension, type 2 diabetes, and/or Alzheimer's dementia. The rest of the participants were healthy. Retinal images were captured by a hand-held, non-mydriatic fundus camera and quantification of the microvascular complexity was performed by using Sholl's, box-counting fractal, and lacunarity analysis. In the healthy subjects, increasing chronological age was associated with lower retinal microvascular complexity measured by Sholl's analysis. Decreased box-counting fractal dimension was present in old patients, and this decrease was 2.1 times faster in participants who had age-related diseases (p = 0.047). Retinal microvascular complexity could be a promising new biomarker of biological age. The data from this study is the first of this kind collected in Montenegro. It is freely available for use.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信