药物再利用：数据库和管道。

IF 3.4 3区医学 Q2 CLINICAL NEUROLOGY

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-07-25 DOI:10.1017/S1092852923002365

Arjun V Kowshik, Megha Manoj, Siddarth Sowmyanarayan, Jhinuk Chatterjee

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引用次数: 0

摘要

药物再利用的概念主要是对已经过安全性试验的药物分子进行重新定位。药物再利用有不同的策略。基于网络的策略侧重于在分子环境中评估药物组合，多靶点命中和药物相互作用分析。任何硅学策略的实施都需要多个数据库和管道来执行筛选合适药物的过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Drug repurposing: databases and pipelines.

The concept of drug repurposing is focused on the repositioning of drug molecules that have already undergone safety trials. There are different strategies for drug repurposing. Network-based strategy focuses on the evaluation of drug combinations in a molecular environment with multi-target hits and analysis of drug interactions. Implementation of any in silico strategy requires several databases and pipelines for executing the process of shortlisting appropriate drugs.

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来源期刊

CNS Spectrums 医学-精神病学

CiteScore

6.20

自引率

6.10%

发文量

239

审稿时长

>12 weeks

期刊介绍： CNS Spectrums covers all aspects of the clinical neurosciences, neurotherapeutics, and neuropsychopharmacology, particularly those pertinent to the clinician and clinical investigator. The journal features focused, in-depth reviews, perspectives, and original research articles. New therapeutics of all types in psychiatry, mental health, and neurology are emphasized, especially first in man studies, proof of concept studies, and translational basic neuroscience studies. Subject coverage spans the full spectrum of neuropsychiatry, focusing on those crossing traditional boundaries between neurology and psychiatry.