程序性死亡配体 1 和肿瘤浸润淋巴细胞（TILs）--TIL 密度低可能预示 T1 喉癌的长期预后较差。

IF 3.4 3区医学 Q1 PATHOLOGY

Virchows Archiv Pub Date : 2024-08-01 Epub Date: 2023-07-18 DOI:10.1007/s00428-023-03586-7

Pihla Pakkanen, Taru Ilmarinen, Elina Halme, Heikki Irjala, Petri Koivunen, Matti Pukkila, Sami Ventelä, Alhadi Almangush, Eva-Maria Birkman, Outi Lindgren, Virva Pohjolainen, Nelli Sjöblom, Caj Haglund, Jaana Hagström, Leena-Maija Aaltonen

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引用次数: 0

摘要

我们评估了程序性死亡配体1（PD-L1）和肿瘤浸润淋巴细胞（TILs）在T1声门喉鳞状细胞癌（LSCC）中的预后作用。研究纳入了2003年至2013年期间在芬兰五所大学医院接受治疗的T1声门喉鳞状细胞癌患者（n = 174）。组织芯片 (TMA) 块用于 PD-L1 免疫组化。从整个组织切片的瘤内和基质区域对TIL进行评分。在174名患者中，92人（53%）的PD-L1水平为阴性，66人（38%）为中度，16人（9%）为高度。在对 TIL 进行分析的 80 例患者中，50 例（63%）的基质 TIL 密度较低，30 例（38%）较高。局部复发或喉部新发原发性肿瘤患者的TIL密度低于其他患者（P = 0.047）。PD-L1高表达和低基质TIL密度与较差的5年疾病特异性生存率相关（85% vs. 100%，p = 0.02）。总之，在接受T1声门LSCC治疗的患者中，低基质TIL密度与喉局部复发和新的原发肿瘤有关。PD-L1的高表达与低基质TIL密度可能与T1声门LSCC患者的生存率降低有关。

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Programmed death-ligand 1 and tumor-infiltrating lymphocytes (TILs) - low TIL density may predict poorer long-term prognosis in T1 laryngeal cancer.

We evaluated the prognostic role of programmed death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in T1 glottic laryngeal squamous cell carcinoma (LSCC). T1 glottic LSCC patients (n = 174) treated at five Finnish university hospitals between 2003 and 2013 were included. Tissue microarray (TMA) blocks were used for PD-L1 immunohistochemistry. TILs were scored from intratumoral and stromal regions in whole tissue sections. Of 174 patients, 92 (53%) had negative, 66 (38%) intermediate, and 16 (9%) high PD-L1 levels. Of 80 patients whose TILs were analyzed, 50 (63%) had low and 30 (38%) high stromal TIL density. Patients with a local recurrence or a new primary tumor of the larynx had lower TIL density than had other patients (p = 0.047). High PD-L1 expression with low stromal TIL density was associated with inferior 5-year disease-specific survival (85% vs. 100%, p = 0.02). In conclusion, in patients treated for T1 glottic LSCC, low stromal TIL density was associated with local recurrences and new primary tumors of the larynx. High PD-L1 expression with low stromal TIL density may be associated with worse survival in T1 glottic LSCC.

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来源期刊

Virchows Archiv 医学-病理学

CiteScore

7.40

自引率

2.90%

发文量

204

审稿时长

4-8 weeks

期刊介绍： Manuscripts of original studies reinforcing the evidence base of modern diagnostic pathology, using immunocytochemical, molecular and ultrastructural techniques, will be welcomed. In addition, papers on critical evaluation of diagnostic criteria but also broadsheets and guidelines with a solid evidence base will be considered. Consideration will also be given to reports of work in other fields relevant to the understanding of human pathology as well as manuscripts on the application of new methods and techniques in pathology. Submission of purely experimental articles is discouraged but manuscripts on experimental work applicable to diagnostic pathology are welcomed. Biomarker studies are welcomed but need to abide by strict rules (e.g. REMARK) of adequate sample size and relevant marker choice. Single marker studies on limited patient series without validated application will as a rule not be considered. Case reports will only be considered when they provide substantial new information with an impact on understanding disease or diagnostic practice.