细胞治疗主动脉瘤的现状综述。

IF 5 3区 医学 Q2 IMMUNOLOGY
Aika Yamawaki-Ogata, Masato Mutsuga, Yuji Narita
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引用次数: 1

摘要

主动脉瘤(AA)被定义为局灶性主动脉扩张,主要发生在老年人和与动脉粥样硬化相关的慢性炎症。动脉瘤壁是一个复杂的炎症环境,其特征是内皮功能障碍、巨噬细胞活化、血管平滑肌细胞(VSMC)凋亡,以及浸润的炎症细胞如巨噬细胞、T细胞和B细胞、树突状细胞、中性粒细胞、肥大细胞和自然杀伤细胞分泌促炎分子和基质金属蛋白酶(MMPs)。迄今为止,对干细胞的研究已经开展了相当多的研究,越来越多的证据表明,炎症和组织修复可以通过干细胞/祖细胞的功能来控制。本文综述了目前基于细胞的治疗AA的方法,包括间充质干细胞、VSMCs、多系分化应激耐受细胞和抗炎M2巨噬细胞。这些细胞通过调节炎症环境,包括降低促炎分子和MMPs的活性,增加抗炎分子,调节VSMC表型和保留弹性蛋白,在AA治疗中产生有益的结果。本文还详细介绍了其病理生理机制的研究和目前的临床试验进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A review of current status of cell-based therapies for aortic aneurysms.

A review of current status of cell-based therapies for aortic aneurysms.

An aortic aneurysm (AA) is defined as focal aortic dilation that occurs mainly with older age and with chronic inflammation associated with atherosclerosis. The aneurysmal wall is a complex inflammatory environment characterized by endothelial dysfunction, macrophage activation, vascular smooth muscle cell (VSMC) apoptosis, and the production of proinflammatory molecules and matrix metalloproteases (MMPs) secreted by infiltrated inflammatory cells such as macrophages, T and B cells, dendritic cells, neutrophils, mast cells, and natural killer cells. To date, a considerable number of studies have been conducted on stem cell research, and growing evidence indicates that inflammation and tissue repair can be controlled through the functions of stem/progenitor cells. This review summarizes current cell-based therapies for AA, involving mesenchymal stem cells, VSMCs, multilineage-differentiating stress-enduring cells, and anti-inflammatory M2 macrophages. These cells produce beneficial outcomes in AA treatment by modulating the inflammatory environment, including decreasing the activity of proinflammatory molecules and MMPs, increasing anti-inflammatory molecules, modulating VSMC phenotypes, and preserving elastin. This article also describes detailed studies on pathophysiological mechanisms and the current progress of clinical trials.

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来源期刊
CiteScore
11.10
自引率
1.20%
发文量
45
审稿时长
11 weeks
期刊介绍: Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.
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