后代出生时与妊娠 BMI 相关的表观遗传标记可预测后代从婴儿期到 26 岁的 BMI 轨迹。

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Obesity Science & Practice Pub Date : 2023-01-09 eCollection Date: 2023-08-01 DOI:10.1002/osp4.660
Vimala Devi Janjanam, Susan Ewart, Hongmei Zhang, Yu Jiang, Hasan Arshad, Ali H Ziyab, Wilfried Karmaus
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引用次数: 0

摘要

目的:迄今为止,表观遗传学研究发现,不同的DNA甲基化(DNAm)与后代出生时的妊娠体重指数(BMI)有关。本研究调查了在后代中发现的 DNAm 是否也与婴儿期至 26 岁期间的体重指数轨迹有关:调查了英国怀特岛出生队列中 794 名参与者的数据,以研究 BMI 轨迹与出生时妊娠 BMI 相关 DNAm 之间的关系。应用多项式逻辑回归模型检验了之前三项全表观基因组关联研究中报告的1090个DNAm位点与BMI轨迹之间的关联:结果:DNAm位点cg23089913(NANOS1)和cg13217064(SOX14)分别与早期持续肥胖(EPO)和延迟超重(DOW)轨迹相关。cg23089913的甲基化程度越高,属于EPO轨迹的几率越低(OR:0.84;95% CI:0.76-0.93),而cg13217064的甲基化程度越高,属于DOW轨迹的几率是正常轨迹的1.4倍[首次在线发表后,于2023年2月22日添加了更正:前一句中DNAm位点cg23089913的范围由 "较低 "改为 "较高"]。在性别分层分析中,女性参与者的 cg13217064 发生 DOW 的几率是男性的 1.8 倍,而在男性中却没有观察到这种关联:结论:新生儿中 cg23089913(NANOS1)和 cg13217064(SOX14)甲基化的偏差可能会改变体重超标的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Offspring epigenetic markers at birth related to gestational BMI predict offspring BMI-trajectories from infancy to 26 years.

Offspring epigenetic markers at birth related to gestational BMI predict offspring BMI-trajectories from infancy to 26 years.

Offspring epigenetic markers at birth related to gestational BMI predict offspring BMI-trajectories from infancy to 26 years.

Offspring epigenetic markers at birth related to gestational BMI predict offspring BMI-trajectories from infancy to 26 years.

Objective: To date, epigenetic studies identified differential DNA methylation (DNAm) related to gestational-body mass index (BMI) in offspring at birth. This study investigated whether the identified DNAm in offspring were also associated with BMI trajectories from infancy to age 26 years.

Methods: Data of 794 participants from Isle of Wight birth cohort in UK were investigated to study association between BMI trajectories and DNAm related to gestational-BMI at birth. Multinominal logistic regression models were applied to test the association between 1090 DNAm sites reported in three prior epigenome-wide association studies and BMI trajectories.

Results: DNAm site cg23089913 (NANOS1) and cg13217064 (SOX14) were associated with early persistent obesity (EPO) and delayed overweight (DOW) trajectories respectively. A higher methylation of cg23089913 showed low odds of being in EPO trajectory (OR: 0.84; 95% CI: 0.76-0.93) while higher methylation of cg13217064 resulted in 1.4-times the odds of being in DOW trajectory when compared to the normal trajectory [Correction added on 22 February 2023, after first online publication: Range of the DNAm site cg23089913 has been changed from 'lower' to 'higher' in the preceding sentence.]. In a gender-stratified analysis, the odds of developing into DOW was 1.8 times in female participants for cg13217064 while not such association was observed in males.

Conclusions: Deviations in methylation of cg23089913 (NANOS1) and cg13217064 (SOX14) in newborns may change the risk of having excess body weight.

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来源期刊
Obesity Science & Practice
Obesity Science & Practice ENDOCRINOLOGY & METABOLISM-
CiteScore
4.20
自引率
4.50%
发文量
73
审稿时长
29 weeks
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