手性碘苯胺-乳酸基酮α-功能化催化剂的合成

IF 3.3 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Organic & Inorganic Au Pub Date : 2023-05-09 DOI:10.1021/acsorginorgau.3c00012

Rawiyah Alkahtani, and , Thomas Wirth*,

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引用次数: 0

摘要

高效合成了一类具有C1和C2对称性的手性碘代苯胺乳酸基催化剂。对新催化剂和先前报道的催化剂之间的反应性和选择性进行了比较。新型催化剂在较短的反应时间内促进了酮的α-氧磺酰基化，产率高达99%。介绍了氧磺酰化反应的范围，形成了各种已报道的和新的产物，对映选择性高达83%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones

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Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones

A family of chiral iodoaniline-lactate based catalysts with C₁ and C₂ symmetry were efficiently synthesized. Comparisons between the reactivity and selectivity between the new and previously reported catalysts are made. The new catalysts promoted the α-oxysulfonylation of ketones in shorter reaction times and with higher yields of up to 99%. A scope for the oxysulfonylation reaction is presented, forming a variety of reported and novel products with enantioselectivities of up to 83%.

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来源期刊

ACS Organic & Inorganic Au 有机化学、无机化学-

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： ACS Organic & Inorganic Au is an open access journal that publishes original experimental and theoretical/computational studies on organic organometallic inorganic crystal growth and engineering and organic process chemistry. Short letters comprehensive articles reviews and perspectives are welcome on topics that include:Organic chemistry Organometallic chemistry Inorganic Chemistry and Organic Process Chemistry.