年龄和肥胖对丹麦 COVID-19 住院患者预后的影响:一项全国性队列研究。

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Obesity Science & Practice Pub Date : 2023-01-17 eCollection Date: 2023-08-01 DOI:10.1002/osp4.659
Anton Lund Andersen, Sigrid Bjerge Gribsholt, Lars Pedersen, Reimar Wernich Thomsen, Thomas Lars Benfield, Ole Søgaard, Stig Lønberg Nielsen, Lars Haukali Omland, Birgitte Lindegaard, Bjørn Richelsen, Jacob Bodilsen, Jens Meldgaard Bruun
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引用次数: 0

摘要

目的:肥胖可能会改变感染冠状病毒病 2019(COVID-19)的严重程度。年龄可能会影响肥胖患者的体重与 COVID-19 感染严重程度之间的关系。本研究的目的是研究在大流行初期因感染COVID-19而住院的丹麦队列中肥胖与感染严重程度之间的关系:患者和方法:基于全国性临床数据库的数据:COVID-DK的数据,比较了肥胖和非肥胖患者入住重症监护室(ICU)、进行有创机械通气(IMV)和死亡的风险。我们研究了肥胖与年龄的交互作用,并使用治疗加权反概率回归法调整混杂因素:在 524 名患者中,142 人(27%)住进了重症监护室,112 人(21%)需要进行 IMV,109 人(21%)死亡。与没有肥胖症的 COVID-19 患者相比,肥胖症患者入住 ICU(相对风险 [RR] 1.19,95% 置信区间 [CI] 0.88;1.60)、接受 IMV(RR 1.23,CI 0.86;1.75)和死亡(RR 1.21,CI 0.84;1.75)的风险均无显著增加。有肥胖症的 COVID-19 患者,结论:在住院的 COVID-19 患者中,肥胖会使入住 ICU、IMV 和死亡的风险增加约 20%,尽管这些关系未达到统计学意义。COVID-19 肥胖症患者和
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The impact of age and obesity on outcomes among patients hospitalized with COVID-19 in Denmark: A nationwide cohort study.

The impact of age and obesity on outcomes among patients hospitalized with COVID-19 in Denmark: A nationwide cohort study.

The impact of age and obesity on outcomes among patients hospitalized with COVID-19 in Denmark: A nationwide cohort study.

The impact of age and obesity on outcomes among patients hospitalized with COVID-19 in Denmark: A nationwide cohort study.

Purpose: Obesity may alter the severity of infection with Coronavirus disease 2019 (COVID-19). Age may impact the association between body weight and severity of COVID-19 in patients with obesity. The aim of the study was to examine the association between obesity and severity of infection in a Danish cohort hospitalized with COVID-19 in the initial wave of the pandemic.

Patients and methods: Based on data from the nationwide, clinical database: COVID-DK, risks of intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), and mortality were compared among patients with and without obesity. Interaction with age was examined and we used Inverse Probability of Treatment Weighting regression for confounder adjustment.

Results: Among 524 patients, 142 (27%) were admitted to the ICU, 112 (21%) required IMV, and 109 (21%) died. Compared to COVID-19 patients without obesity, patients with obesity displayed a non-significant increased risk of ICU admission (Relative Risk [RR] 1.19, 95% Confidence Interval [CI] 0.88; 1.60), IMV (RR 1.23, CI 0.86; 1.75) and mortality (RR 1.21, CI 0.84; 1.75). COVID-19 patients with obesity, <60 years had highly increased risk of ICU admission (RR 1.92, CI 1.14; 3.24) and IMV (RR 1.95, CI 1.09; 3.49).

Conclusions: In hospitalized COVID-19 patients, obesity conferred an approximately 20% increased risk for ICU admission, IMV, and death, although these relationships did not reach statistical significance. COVID-19 patients with obesity and <60 years had an almost doubled risk of ICU admission and IMV.

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来源期刊
Obesity Science & Practice
Obesity Science & Practice ENDOCRINOLOGY & METABOLISM-
CiteScore
4.20
自引率
4.50%
发文量
73
审稿时长
29 weeks
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