PIWI-相互作用RNA(piRNA):关于其生物发生、功能和在癌症中的新作用的叙述性综述。

IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Asian Biomedicine Pub Date : 2022-02-28 eCollection Date: 2022-02-01 DOI:10.2478/abm-2022-0002
Pritha Mukherjee, Shamee Bhattacharjee, Deba Prasad Mandal
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引用次数: 1

摘要

癌症在许多方面仍然难以捉摸,尤其是在病因和控制方面。经过蛋白质分析、基因筛选和突变研究,科学家们现在将注意力转向了表观遗传调控。这一新领域揭示了非编码RNA(ncRNA)的世界。尽管非常复杂且经常令人困惑,但ncRNA结构域现在是癌症表观遗传学控制最具吸引力的分子标记之一。长ncRNA和微小RNA(miRNA)在非编码基因组中研究得最好,并积累了大量关于其在癌症中的抑制和促进作用的数据。ncRNA的另一个领域是PIWI相互作用RNA(piRNA)的世界。piRNA最初是通过果蝇卵巢中种系干细胞的不对称分裂发现的,它具有与哺乳动物蛋白质结合的独特能力,类似于果蝇中P元素诱导的弱睾丸(PIWI),并能够沉默转座子。在简要介绍其发现时间表后,本叙述性综述涵盖了piRNA在癌症中的生物发生、功能和作用。在细胞增殖、干性维持、转移和总生存率的章节中强调了对癌症的影响,该综述最后讨论了另一类小ncRNA,即piRNA-like RNA(piR-Ls)的最新发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

PIWI-interacting RNA (piRNA): a narrative review of its biogenesis, function, and emerging role in lung cancer.

PIWI-interacting RNA (piRNA): a narrative review of its biogenesis, function, and emerging role in lung cancer.

PIWI-interacting RNA (piRNA): a narrative review of its biogenesis, function, and emerging role in lung cancer.

Cancer remains elusive in many aspects, especially in its causes and control. After protein profiling, genetic screening, and mutation studies, scientists now have turned their attention to epigenetic modulation. This new arena has brought to light the world of noncoding RNA (ncRNA). Although very complicated and often confusing, ncRNA domains are now among the most attractive molecular markers for epigenetic control of cancer. Long ncRNA and microRNA (miRNA) have been studied best among the noncoding genome and huge data have accumulated regarding their inhibitory and promoting effects in cancer. Another sector of ncRNAs is the world of PIWI-interacting RNAs (piRNAs). Initially discovered with the asymmetric division of germline stem cells in the Drosophila ovary, piRNAs have a unique capability to associate with mammalian proteins analogous to P-element induced wimpy testis (PIWI) in Drosophila and are capable of silencing transposons. After a brief introduction to its discovery timelines, the present narrative review covers the biogenesis, function, and role of piRNAs in lung cancer. The effects on lung cancer are highlighted under sections of cell proliferation, stemness maintenance, metastasis, and overall survival, and the review concludes with a discussion of recent discoveries of another class of small ncRNAs, the piRNA-like RNAs (piR-Ls).

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来源期刊
Asian Biomedicine
Asian Biomedicine 医学-医学:研究与实验
CiteScore
1.20
自引率
0.00%
发文量
24
审稿时长
6-12 weeks
期刊介绍: Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.
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