使用大麻和大麻素后的自杀风险:概括性综述。

IF 8.3 2区 医学 Q1 Medicine
Ahmad Shamabadi, Ali Ahmadzade, Kasra Pirahesh, Alireza Hasanzadeh, Hassan Asadigandomani
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引用次数: 0

摘要

自杀的患病率和负担不断增加,导致了许多研究来确定其风险因素。大麻是自杀受害者毒理学测试中发现的最常见的非法物质。本研究旨在确定和评估调查使用大麻和大麻素后自杀的系统综述。对七个数据库和两个登记处进行了无限制的搜索,以进行调查大麻对自杀影响的系统审查。AMSTAR-2用于质量评估,校正覆盖面积和引文矩阵用于确定重叠。纳入了25项研究,其中24项是关于娱乐用途,1项是关于治疗用途。只有三项关于娱乐用途的研究报告没有效果或结果不一致。有证据表明,在普通人群、退伍军人、双相情感障碍或严重抑郁症患者中,大麻使用与自杀意念和企图之间存在正相关。还提到了大麻与自杀意念之间的双向因果关系。此外,据报道,较年轻的起始年龄、长期使用和大量消费与更糟糕的自杀结果有关。相反,目前的证据表明,治疗性大麻是安全的。总之,文献支持大麻在娱乐用途中的自杀性关联,但认为大麻二酚治疗是安全的。建议采用定量和介入方法进行进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Suicidality risk after using cannabis and cannabinoids: An umbrella review.

Suicidality risk after using cannabis and cannabinoids: An umbrella review.

The increasing prevalence and burden of suicide have led to numerous studies to identify its risk factors. Cannabis is the most common illicit substance detected in suicide victims' toxicology tests. This study aims to identify and appraise systematic reviews investigating suicidality after using cannabis and cannabinoids. Seven databases and two registries were searched without restrictions for systematic reviews investigating cannabis effects on suicidality. AMSTAR-2 was used for quality assessment and corrected covered area and citation matrix were used to determine overlap. Twenty-five studies were included, of which 24 were on recreational use and one was on therapeutic use. Only three of the studies on recreational use reported no effect or inconsistent results. Evidence generally showed a positive association between cannabis use and suicidal ideation and attempt among the general population, military veterans, and bipolar or major depression patients. A bidirectional causal association between cannabis and suicidal ideation was also mentioned. Moreover, a younger age of initiation, long-term use, and heavy consumption were reported to be associated with even worse suicidal outcomes. On the contrary, current evidence indicates that the therapeutic cannabis is safe. In conclusion, the literature supports the cannabis-suicidality association in recreational use but considers cannabidiol safe for treatment. Further studies with quantitative and interventional approaches are recommended.

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来源期刊
Dialogues in Clinical Neuroscience
Dialogues in Clinical Neuroscience Medicine-Psychiatry and Mental Health
CiteScore
19.30
自引率
1.20%
发文量
1
期刊介绍: Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.
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