牛耳草分支对小鼠脂肪细胞、3t3-l1细胞和高脂饮食肥胖小鼠的抗肥胖作用

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Pharmazie Pub Date : 2023-07-01 DOI:10.1691/ph.2023.3518

Min Yeong Choi, Jeong Won Choi, Hyeok Jin Choi, Seung Woo Im, Gwang Hun Park, Jin Boo Jeong

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引用次数: 1

摘要

据报道，羊角草具有多种药理活性，但大多数研究都是用其果实进行的。然而，从经济的角度来看，利用废弃的树叶和树枝作为副产品是非常有价值的。本研究考察了土茯苓提取物(HDB)的体内和体外抗肥胖活性，以评价其作为抗肥胖药物的适用性。在分化的3T3-L1细胞中，HDB抑制脂滴积聚。HDB下调CEBPα、PPARγ和perilipin-1，上调ATGL、p-HSL、HSL、p-AMPK、UCP-1、PGC-1α、PRDM16、LC3-II和p62/SQSTM1。此外，HDB增加了游离甘油含量。在hfd诱导的肥胖小鼠中，HDB降低了体重和总脂肪重量。此外，HDB降低血液ldl -胆固醇、血液总胆固醇和血液甘油三酯。上述结果表明，HDB具有抗肥胖活性，可作为一种健康的减肥功能性食品剂。

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Anti-Obesity Effects of Hovenia Dulcis Branches in Mouse Adipocytes, 3t3-l1 Cells, and High-Fat Diet Obese Mice.

Hovenia dulcis has been reported to have various pharmacological activities, but most studies were done with its fruits. However, from an economic point of view, the use of discarded leaves and branches as by-products is very valuable. In this study, thein vitro andin vivo anti-obesity activities of Hovenia dulcis branch extract (HDB) were investigated to evaluate the applicability of HDB as an anti-obesity agent. In differentiated 3T3-L1 cells, HDB inhibited lipid droplet accumulation. And HDB downregulated CEBPα, PPARγ, and perilipin-1, and upregulated ATGL, p-HSL, HSL, p-AMPK, UCP-1, PGC-1α, PRDM16, LC3-II, and p62/SQSTM1. In addition, HDB increased free glycerol content. In HFD-induced obese mice, HDB reduced body weight and total fat weight. In addition, HDB decreased blood LDL-cholesterol, blood total cholesterol, and blood triglyceride. These results indicate that HDB has anti-obesity activity and HDB can be used as a healthy functional food agent for weight reduction.

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来源期刊

Pharmazie 医学-化学综合

CiteScore

3.10

自引率

0.00%

发文量

审稿时长

1.2 months

期刊介绍： The journal DiePharmazie publishs reviews, experimental studies, letters to the editor, as well as book reviews. The following fields of pharmacy are covered: Pharmaceutical and medicinal chemistry; Pharmaceutical analysis and drug control; Pharmaceutical technolgy; Biopharmacy (biopharmaceutics, pharmacokinetics, biotransformation); Experimental and clinical pharmacology; Pharmaceutical biology (pharmacognosy); Clinical pharmacy; History of pharmacy.