精神分裂症与COVID-19大流行:从生物医学角度的叙事回顾。

IF 5.2 3区 医学 Q1 PSYCHIATRY
Krzysztof Kowalski, Błażej Misiak
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引用次数: 0

摘要

2020年爆发的2019冠状病毒病(COVID-19)大流行导致全球精神卫生状况迅速恶化。患有严重精神障碍的患者,包括精神分裂症患者,被感染的风险更高。严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)的神经侵袭潜力已得到证实。本文的目的是对精神分裂症和COVID-19之间的多维关联进行叙述和全面回顾,特别强调常见的生物学途径。在PubMed数据库中进行了在线搜索,涵盖了截止到2022年9月17日的出版期。搜索词包括“精神病”、“精神分裂症”、“炎症”和“COVID-19”。精神分裂症被视为一种神经炎症状态,与COVID-19具有几种相同的神经生物学机制。环境压力、精神分裂症的常见合并症和抗精神病药物治疗的不良反应与COVID-19的更高严重程度和死亡率相关。此外,还观察到更频繁的精神病复发,这可能与较低的治疗依从性有关。在临床表现方面,在大流行期间,在精神分裂症患者中发现了更高水平的阴性症状。有必要改进精神卫生保健政策和调整治疗,以保护精神分裂症患者,他们是特别容易受到COVID-19大流行后果影响的人群。未来的研究将显示产前感染SARS-CoV-2是否会增加患精神病的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Schizophrenia and the COVID-19 pandemic: A narrative review from the biomedical perspective.

The outbreak of the Coronavirus Disease 2019 (COVID-19) pandemic in 2020 caused a rapid worsening of global mental health. Patients with severe mental disorders, including schizophrenia, are at higher risk of being infected. The neuroinvasive potential of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has been confirmed. The aim of this article was to present a narrative and comprehensive review of multidimensional associations between schizophrenia and COVID-19 with special emphasis on common biological pathways. Online searches were performed in the PubMed database and covered the publication period until September 17, 2022. Search terms included "psychosis", "schizophrenia", "inflammation" and "COVID-19". Viewed as a neuroinflammatory state, schizophrenia shares several neurobiological mechanisms with the COVID-19. Environmental stress, common comorbidities of schizophrenia and adverse effects of antipsychotic treatment are associated with the higher severity and mortality of the COVID-19. Additionally, more frequent relapses of psychosis have been observed, and might be related to lower treatment adherence. In the context of clinical manifestation, higher level of negative symptoms has been identified among patients with schizophrenia during the pandemic. Improvements in mental health care policy and treatment adjustment are necessary to protect people with schizophrenia who are the population that is particularly vulnerable to the consequences of the COVID-19 pandemic. Future research will show if prenatal infection with the SARS-CoV-2 increases a risk of psychosis.

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来源期刊
自引率
3.30%
发文量
58
期刊介绍: The Spanish Journal of Psychiatry and Mental Health (SJPMH), incorporated into ISSN 1888-9891, is the official scientific publication of the Spanish Society of Psychiatry and Mental Health. The journal focuses on studying mental illnesses, their pathological processes, and their psychosocial consequences, and aims to disseminate scientific advances in all areas related to mental health and illness. SJPMH accepts unpublished works on psychiatry and mental health, including their medical and social implications. The journal provides space for research in the biological, clinical, and psychosocial fields. Manuscripts undergo peer-review by external reviewers before being accepted for publication. SJPMH is indexed in Index Medicus/Medline, IBECS, Social Sciences Citation Index Journal Citation Reports/Social Sciences Edition, and Current Contents/Social and Behavioral Sciences.
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