细胞衰老在炎性肺病中的作用

IF 9.3 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Cong Xie , Mai Maititusun Ya Likun , Qing-li Luo , Jing-cheng Dong
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引用次数: 4

摘要

细胞衰老是衰老的一个特征性标志,通常指的是永久性细胞增殖停滞,是癌症和年龄相关疾病发病机制的重要因素。大量必要的科学研究表明,衰老细胞聚集和衰老相关分泌表型(SASP)成分的释放也会导致肺部炎症性疾病。在这项研究中,回顾了细胞衰老和表型的最新科学进展,包括它们对肺部炎症的影响,以及这些发现对理解细胞和发育生物学的潜在机制和临床相关性的贡献。在十几种促衰老刺激中,无法修复的DNA损伤、氧化应激和端粒侵蚀都是衰老细胞长期积累的关键,导致呼吸系统持续的炎症应激激活。这篇综述提出了细胞衰老在炎症性肺病中的一个新作用,随后确定了主要的歧义,从而进一步了解了这一事件以及控制细胞衰老和促炎反应激活的潜力。此外,本研究还提出了调节细胞衰老的新治疗策略,这些策略可能有助于减轻炎症性肺部疾病并改善疾病结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Role of cellular senescence in inflammatory lung diseases

Role of cellular senescence in inflammatory lung diseases

Cellular senescence, a characteristic sign of aging, classically refers to permanent cell proliferation arrest and is a vital contributor to the pathogenesis of cancer and age-related illnesses. A lot of imperative scientific research has shown that senescent cell aggregation and the release of senescence-associated secretory phenotype (SASP) components can cause lung inflammatory diseases as well. In this study, the most recent scientific progress on cellular senescence and phenotypes was reviewed, including their impact on lung inflammation and the contributions of these findings to understanding the underlying mechanisms and clinical relevance of cell and developmental biology. Within a dozen pro-senescent stimuli, the irreparable DNA damage, oxidative stress, and telomere erosion are all crucial in the long-term accumulation of senescent cells, resulting in sustained inflammatory stress activation in the respiratory system. An emerging role for cellular senescence in inflammatory lung diseases was proposed in this review, followed by the identification of the main ambiguities, thus further understanding this event and the potential to control cellular senescence and pro-inflammatory response activation. In addition, novel therapeutic strategies for the modulation of cellular senescence that might help to attenuate inflammatory lung conditions and improve disease outcomes were also presented in this research.

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来源期刊
Cytokine & Growth Factor Reviews
Cytokine & Growth Factor Reviews 生物-生化与分子生物学
CiteScore
21.10
自引率
1.50%
发文量
61
审稿时长
22 days
期刊介绍: Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.
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