血凝素稳定性是甲型流感病毒通过空气传播的关键决定因素

IF 5.7 2区 医学 Q1 VIROLOGY
Ilona I Tosheva , Kain S Saygan , Suzanne MA Mijnhardt , Charles J Russell , Pieter LA Fraaij , Sander Herfst
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引用次数: 0

摘要

为了引起流行病,人畜共患呼吸道病毒需要适应通过(间接或直接)接触或通过飞沫和气溶胶通过空气在人体内复制和传播。为了使甲型流感病毒通过空气传播,必须改变三种表型的病毒特性,其中受体结合特异性和聚合酶活性已经得到了很好的研究。然而,第三种适应性特性,血凝素(HA)酸稳定性,却鲜为人知。最近的研究表明,HA酸的稳定性和病毒在空气中的存活率之间可能存在相关性,这表明由气道或飞沫中的低pH值引发的HA的过早构象变化可能会使病毒在到达新宿主之前不受感染。我们在此总结了HA酸稳定性对空气传播影响的(动物)研究的可用数据,并假设其他呼吸道病毒的传播性也可能受到呼吸道酸性环境的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hemagglutinin stability as a key determinant of influenza A virus transmission via air

To cause pandemics, zoonotic respiratory viruses need to adapt to replication in and spread between humans, either via (indirect or direct) contact or through the air via droplets and aerosols. To render influenza A viruses transmissible via air, three phenotypic viral properties must change, of which receptor-binding specificity and polymerase activity have been well studied. However, the third adaptive property, hemagglutinin (HA) acid stability, is less understood. Recent studies show that there may be a correlation between HA acid stability and virus survival in the air, suggesting that a premature conformational change of HA, triggered by low pH in the airways or droplets, may render viruses noninfectious before they can reach a new host. We here summarize available data from (animal) studies on the impact of HA acid stability on airborne transmission and hypothesize that the transmissibility of other respiratory viruses may also be impacted by an acidic environment in the airways.

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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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