血清胱抑素c与肌酐比值作为骨质疏松性骨折预测指标的临床意义

IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL
Ichiro Yoshii MD, Naoya Sawada MD, Tatsumi Chijiwa MD
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引用次数: 0

摘要

背景检测合适的指标对于预防偶发骨质疏松性骨折是有价值的。我们对血清胱抑素c与肌酐比值(CysC/Cr)作为预测重大骨质疏松性骨折(MOF)的替代指标的意义进行了统计学评估。方法选择同时测量腰椎和股骨近端CysC/Cr和骨密度的符合条件的患者,并在回顾性区域队列数据中观察其基线后5年的骨折史。随访至终止或首次骨质疏松性骨折的患者被纳入研究,随访缺失或死亡被排除在外。使用cox回归分析对骨质疏松性骨折的候选危险因素进行风险比测试。对风险比明显较高的因素进行受试者工作特征试验,并采用Kaplan-Meier生存分析进行评估,以确定这些因素的风险比。结果共纳入175例患者,其中28例发生MOF,其中男性38例,女性137例。平均年龄70.2岁。MOF、超跌倒能力、生活方式相关疾病、慢性肾脏疾病≥3a级、CysC/Cr较高时,风险比显著升高。所有参数均有截止指数,且风险比显著升高。结论CysC/Cr可作为骨质疏松性骨折发生的预测指标。它可以作为MOF风险的筛查工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clinical significance of serum cystatin C-to-creatinine ratio as a surrogate marker for incident osteoporotic fracture predictions

Clinical significance of serum cystatin C-to-creatinine ratio as a surrogate marker for incident osteoporotic fracture predictions

Background

Detection of appropriate indicators is valuable for preventing incidental osteoporotic fractures. We statistically evaluated the significance of serum cystatin C-to-creatinine ratio (CysC/Cr) as a surrogate marker for incident major osteoporotic fractures (MOF) prediction.

Methods

Eligible patients with simultaneous measurement of CysC/Cr and bone mineral density in the lumbar spine and proximal femur were selected, and their fracture histories until 5 years after baseline were observed in the retrospective area cohort data. Patients who were followed up until termination or the first osteoporotic fracture were included, and loss of follow-up or death was excluded. Candidate risk factors for osteoporotic fractures were tested for risk ratios using a cox regression analysis. Receiver operating characteristic tests were performed on factors with significantly higher risk ratios and evaluated with Kaplan-Meier survival analysis to determine the hazard ratios of the factors.

Results

A total of 175 patients of whom 28 had incident MOF, 38 men, and 137 women, were enrolled. The mean age was 70.2 years. A significantly higher risk ratio was shown in the presence of prevalent MOF, hyper fall-ability, lifestyle-related diseases, chronic kidney diseases ≥ Grade3a, and higher CysC/Cr. All parameters had cutoff indices and showed significantly higher hazard ratios.

Conclusions

These results suggested that CysC/Cr may be a predictive marker of incident osteoporotic fractures. It might work as a screening tool for MOF risk.

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来源期刊
Journal of General and Family Medicine
Journal of General and Family Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
2.10
自引率
6.20%
发文量
79
审稿时长
48 weeks
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