Ihor Krasivskyi, Borko Ivanov, Stephen Gerfer, Clara Großmann, Mariya Mihaylova, Kaveh Eghbalzadeh, Anton Sabashnikov, Antje-Christin Deppe, Parwis Baradaran Rahmanian, Navid Mader, Ilija Djordjevic, Thorsten Wahlers
{"title":"急性冠状动脉综合征冠状动脉旁路移植手术患者的急性中风：预测因素和结果","authors":"Ihor Krasivskyi, Borko Ivanov, Stephen Gerfer, Clara Großmann, Mariya Mihaylova, Kaveh Eghbalzadeh, Anton Sabashnikov, Antje-Christin Deppe, Parwis Baradaran Rahmanian, Navid Mader, Ilija Djordjevic, Thorsten Wahlers","doi":"10.1177/02676591231193636","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Coronary artery bypass grafting (CABG) surgery in patients with acute coronary syndrome (ACS) remains a high-risk procedure and is associated with adverse outcomes. The risk factors of acute stroke in the above-mentioned patients stay unclear and some appropriate data is lacking in the literature. Thus, we aimed to investigate the predictors of acute stroke in patients undergoing CABG surgery in ACS.</p><p><strong>Methods: </strong>The retrospective single-centre cohort analysis was conducted. All patients (<i>n</i> = 1344) who suffered from acute coronary syndrome and underwent CABG procedure at the University hospital Cologne from June 2011 until October 2019 were included in our study. In order to find the risk factors of acute stroke after bypass surgery, patients were divided into two groups (non-stroke group (<i>n</i> = 1297) and stroke group (<i>n</i> = 47)). In order to even above-mentioned groups propensity score matching (PSM) analysis was performed (non-stroke group (<i>n</i> = 46) and stroke group (<i>n</i> = 46).</p><p><strong>Results: </strong>Duration of cardiopulmonary bypass (<i>p</i> = .015) and cross clamp time (<i>p</i> = .006) were significantly longer in patients who suffered stroke. Perioperative myocardial infarction was significantly higher (<i>p</i> = .030) in the stroke group. Likewise, the duration of intensive care unit stay (<i>p</i> < .001) and in-hospital stay (<i>p</i> < .001) were significantly longer in patients with stroke. However, the mortality rate did not differ significantly (<i>p</i> = .131) between above-mentioned groups. Univariate and multivariate analysis showed cardiogenic shock (<i>p</i> = .003), peripheral vascular disease (PVD, <i>p</i> = .025) and previous stroke (<i>p</i> = .045) as relevant independent predictors for acute stroke after CABG procedure in patients with ACS.</p><p><strong>Conclusion: </strong>Based on our findings, acute stroke after bypass surgery in patients with ACS is associated with increased mortality and adverse outcomes. Cardiogenic shock, peripheral vascular disease and previous stroke were independent predictors of stroke after CABG procedure. Therefore, preoperative evaluation of potential risk factors may be crucial to improve postoperative results.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1348-1355"},"PeriodicalIF":1.1000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Acute stroke in patients undergoing coronary artery bypass grafting surgery in acute coronary syndrome: Predictors and outcomes.\",\"authors\":\"Ihor Krasivskyi, Borko Ivanov, Stephen Gerfer, Clara Großmann, Mariya Mihaylova, Kaveh Eghbalzadeh, Anton Sabashnikov, Antje-Christin Deppe, Parwis Baradaran Rahmanian, Navid Mader, Ilija Djordjevic, Thorsten Wahlers\",\"doi\":\"10.1177/02676591231193636\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Coronary artery bypass grafting (CABG) surgery in patients with acute coronary syndrome (ACS) remains a high-risk procedure and is associated with adverse outcomes. The risk factors of acute stroke in the above-mentioned patients stay unclear and some appropriate data is lacking in the literature. Thus, we aimed to investigate the predictors of acute stroke in patients undergoing CABG surgery in ACS.</p><p><strong>Methods: </strong>The retrospective single-centre cohort analysis was conducted. All patients (<i>n</i> = 1344) who suffered from acute coronary syndrome and underwent CABG procedure at the University hospital Cologne from June 2011 until October 2019 were included in our study. In order to find the risk factors of acute stroke after bypass surgery, patients were divided into two groups (non-stroke group (<i>n</i> = 1297) and stroke group (<i>n</i> = 47)). In order to even above-mentioned groups propensity score matching (PSM) analysis was performed (non-stroke group (<i>n</i> = 46) and stroke group (<i>n</i> = 46).</p><p><strong>Results: </strong>Duration of cardiopulmonary bypass (<i>p</i> = .015) and cross clamp time (<i>p</i> = .006) were significantly longer in patients who suffered stroke. Perioperative myocardial infarction was significantly higher (<i>p</i> = .030) in the stroke group. Likewise, the duration of intensive care unit stay (<i>p</i> < .001) and in-hospital stay (<i>p</i> < .001) were significantly longer in patients with stroke. However, the mortality rate did not differ significantly (<i>p</i> = .131) between above-mentioned groups. Univariate and multivariate analysis showed cardiogenic shock (<i>p</i> = .003), peripheral vascular disease (PVD, <i>p</i> = .025) and previous stroke (<i>p</i> = .045) as relevant independent predictors for acute stroke after CABG procedure in patients with ACS.</p><p><strong>Conclusion: </strong>Based on our findings, acute stroke after bypass surgery in patients with ACS is associated with increased mortality and adverse outcomes. Cardiogenic shock, peripheral vascular disease and previous stroke were independent predictors of stroke after CABG procedure. Therefore, preoperative evaluation of potential risk factors may be crucial to improve postoperative results.</p>\",\"PeriodicalId\":49707,\"journal\":{\"name\":\"Perfusion-Uk\",\"volume\":\" \",\"pages\":\"1348-1355\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Perfusion-Uk\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/02676591231193636\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/7/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Perfusion-Uk","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/02676591231193636","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/7/28 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Acute stroke in patients undergoing coronary artery bypass grafting surgery in acute coronary syndrome: Predictors and outcomes.
Objectives: Coronary artery bypass grafting (CABG) surgery in patients with acute coronary syndrome (ACS) remains a high-risk procedure and is associated with adverse outcomes. The risk factors of acute stroke in the above-mentioned patients stay unclear and some appropriate data is lacking in the literature. Thus, we aimed to investigate the predictors of acute stroke in patients undergoing CABG surgery in ACS.
Methods: The retrospective single-centre cohort analysis was conducted. All patients (n = 1344) who suffered from acute coronary syndrome and underwent CABG procedure at the University hospital Cologne from June 2011 until October 2019 were included in our study. In order to find the risk factors of acute stroke after bypass surgery, patients were divided into two groups (non-stroke group (n = 1297) and stroke group (n = 47)). In order to even above-mentioned groups propensity score matching (PSM) analysis was performed (non-stroke group (n = 46) and stroke group (n = 46).
Results: Duration of cardiopulmonary bypass (p = .015) and cross clamp time (p = .006) were significantly longer in patients who suffered stroke. Perioperative myocardial infarction was significantly higher (p = .030) in the stroke group. Likewise, the duration of intensive care unit stay (p < .001) and in-hospital stay (p < .001) were significantly longer in patients with stroke. However, the mortality rate did not differ significantly (p = .131) between above-mentioned groups. Univariate and multivariate analysis showed cardiogenic shock (p = .003), peripheral vascular disease (PVD, p = .025) and previous stroke (p = .045) as relevant independent predictors for acute stroke after CABG procedure in patients with ACS.
Conclusion: Based on our findings, acute stroke after bypass surgery in patients with ACS is associated with increased mortality and adverse outcomes. Cardiogenic shock, peripheral vascular disease and previous stroke were independent predictors of stroke after CABG procedure. Therefore, preoperative evaluation of potential risk factors may be crucial to improve postoperative results.
期刊介绍：
Perfusion is an ISI-ranked, peer-reviewed scholarly journal, which provides current information on all aspects of perfusion, oxygenation and biocompatibility and their use in modern cardiac surgery. The journal is at the forefront of international research and development and presents an appropriately multidisciplinary approach to perfusion science.
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