Aura Angélica López-García, Miguel Ángel Ramos-Choreño, Luis Alejandro Sánchez-Hurtado, Laura Romero-Gutiérrez, Salvador Calleja-Alarcón, Araceli Gudiño-Turrubiates, Natividad Neri-Muñoz, Jesús Manuel Ponce-Sánchez, Tania Colín-Martínez
{"title":"[与COVID-19危重患者死亡率相关的血液学指标]。","authors":"Aura Angélica López-García, Miguel Ángel Ramos-Choreño, Luis Alejandro Sánchez-Hurtado, Laura Romero-Gutiérrez, Salvador Calleja-Alarcón, Araceli Gudiño-Turrubiates, Natividad Neri-Muñoz, Jesús Manuel Ponce-Sánchez, Tania Colín-Martínez","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 disease has represented one of the most important threats to health. The most severe form is acute respiratory distress syndrome (ARDS). The inflammatory response can cause hematologic changes.</p><p><strong>Objective: </strong>To determine the association between the Neutrophil/lymphocyte ratio (NLR) and the mean platelet volume (MPV) associated with mortality in critically ill patients with COVID-19 and ARDS.</p><p><strong>Material and methods: </strong>A retrospective study was carried out in an intensive care unit (ICU) in a public hospital, with patients in critical condition due to COVID-19 and on mechanical ventilation. The clinical characteristics of admission and severity of the disease were recorded. The end point was the ICU discharge condition.</p><p><strong>Results: </strong>162 subjects were gathered, 103 were men, with a mean age of 54.54 ± 13.53 years. 66.7% died in the ICU. The NLR had an area under the curve (aROC) of 0.62, with a cut-off point for mortality of > 7.04, sensitivity of 94.4%, specificity of 29.63%. The VPM had an aROC of 0.65 with a cut-off point > 9.5, sensitivity of 30.84%, and specificity of 92.59%; finally, the APACHE II had an aROC of 0.67 with a cut-off point > 14, sensitivity of 51.4% and specificity of 80%. The NLR presented an odds ratio (OR) of 5.02, the VPM 2.06 and the APACHE II score 1.16.</p><p><strong>Conclusions: </strong>NLR, MPV, and APACHE II at ICU admission are associated with mortality for critically ill patients with COVID-19.</p>","PeriodicalId":21419,"journal":{"name":"Revista médica del Instituto Mexicano del Seguro Social","volume":"61 1","pages":"75-81"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/53/04435117-61-1-75.PMC10395922.pdf","citationCount":"0","resultStr":"{\"title\":\"[Hematological indices associated with mortality in critically ill patients with COVID-19].\",\"authors\":\"Aura Angélica López-García, Miguel Ángel Ramos-Choreño, Luis Alejandro Sánchez-Hurtado, Laura Romero-Gutiérrez, Salvador Calleja-Alarcón, Araceli Gudiño-Turrubiates, Natividad Neri-Muñoz, Jesús Manuel Ponce-Sánchez, Tania Colín-Martínez\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The COVID-19 disease has represented one of the most important threats to health. The most severe form is acute respiratory distress syndrome (ARDS). The inflammatory response can cause hematologic changes.</p><p><strong>Objective: </strong>To determine the association between the Neutrophil/lymphocyte ratio (NLR) and the mean platelet volume (MPV) associated with mortality in critically ill patients with COVID-19 and ARDS.</p><p><strong>Material and methods: </strong>A retrospective study was carried out in an intensive care unit (ICU) in a public hospital, with patients in critical condition due to COVID-19 and on mechanical ventilation. The clinical characteristics of admission and severity of the disease were recorded. The end point was the ICU discharge condition.</p><p><strong>Results: </strong>162 subjects were gathered, 103 were men, with a mean age of 54.54 ± 13.53 years. 66.7% died in the ICU. The NLR had an area under the curve (aROC) of 0.62, with a cut-off point for mortality of > 7.04, sensitivity of 94.4%, specificity of 29.63%. The VPM had an aROC of 0.65 with a cut-off point > 9.5, sensitivity of 30.84%, and specificity of 92.59%; finally, the APACHE II had an aROC of 0.67 with a cut-off point > 14, sensitivity of 51.4% and specificity of 80%. The NLR presented an odds ratio (OR) of 5.02, the VPM 2.06 and the APACHE II score 1.16.</p><p><strong>Conclusions: </strong>NLR, MPV, and APACHE II at ICU admission are associated with mortality for critically ill patients with COVID-19.</p>\",\"PeriodicalId\":21419,\"journal\":{\"name\":\"Revista médica del Instituto Mexicano del Seguro Social\",\"volume\":\"61 1\",\"pages\":\"75-81\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/53/04435117-61-1-75.PMC10395922.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista médica del Instituto Mexicano del Seguro Social\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista médica del Instituto Mexicano del Seguro Social","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Hematological indices associated with mortality in critically ill patients with COVID-19].
Background: The COVID-19 disease has represented one of the most important threats to health. The most severe form is acute respiratory distress syndrome (ARDS). The inflammatory response can cause hematologic changes.
Objective: To determine the association between the Neutrophil/lymphocyte ratio (NLR) and the mean platelet volume (MPV) associated with mortality in critically ill patients with COVID-19 and ARDS.
Material and methods: A retrospective study was carried out in an intensive care unit (ICU) in a public hospital, with patients in critical condition due to COVID-19 and on mechanical ventilation. The clinical characteristics of admission and severity of the disease were recorded. The end point was the ICU discharge condition.
Results: 162 subjects were gathered, 103 were men, with a mean age of 54.54 ± 13.53 years. 66.7% died in the ICU. The NLR had an area under the curve (aROC) of 0.62, with a cut-off point for mortality of > 7.04, sensitivity of 94.4%, specificity of 29.63%. The VPM had an aROC of 0.65 with a cut-off point > 9.5, sensitivity of 30.84%, and specificity of 92.59%; finally, the APACHE II had an aROC of 0.67 with a cut-off point > 14, sensitivity of 51.4% and specificity of 80%. The NLR presented an odds ratio (OR) of 5.02, the VPM 2.06 and the APACHE II score 1.16.
Conclusions: NLR, MPV, and APACHE II at ICU admission are associated with mortality for critically ill patients with COVID-19.
![[Hematological indices associated with mortality in critically ill patients with COVID-19].](https://img.booksci.cn/booksciimg/2023-1/2023120578260963234938772754524.jpg)
![[Hematological indices associated with mortality in critically ill patients with COVID-19].](https://img.booksci.cn/booksciimg/2023-1/2023120578262514131156024749520.jpg)
![[Hematological indices associated with mortality in critically ill patients with COVID-19].](https://img.booksci.cn/booksciimg/2023-1/2023120578285449429300380363534.jpg)
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