腰痛和骨关节炎疼痛:雌激素的视角。

IF 14.3 1区 医学 Q1 CELL & TISSUE ENGINEERING
Huiwen Pang, Shihui Chen, David M Klyne, David Harrich, Wenyuan Ding, Sidong Yang, Felicity Y Han
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引用次数: 0

摘要

腰痛(LBP)是世界上导致残疾的主要原因,其患病率的增长速度比任何其他疼痛状况都要快。椎间盘退变(IVD)和小关节骨性关节炎(FJOA)是腰痛的两种常见原因,两者在老年妇女中比在其他人群中更常见。此外,骨关节炎(OA)和OA疼痛,无论在哪个关节,女性的经历是男性的两倍,这种差异在绝经期被放大。雌激素的变化可能是这些疼痛状态的重要因素。雌激素受体已经在IVD组织和关节附近被发现,强调了雌激素在IVD和关节内部和周围的潜在作用。此外,雌激素补充已被证明在改善IVD退变和OA进展方面有效,表明其作为治疗腰痛和OA疼痛的潜在用途。这篇综述通过总结最近的临床前和临床研究结果,全面探讨了雌激素与这些疼痛状况之间的关系。本文讨论了雌激素可能缓解与IVD变性和FJOA和OA疼痛相关的腰痛的潜在分子机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Low back pain and osteoarthritis pain: a perspective of estrogen.

Low back pain and osteoarthritis pain: a perspective of estrogen.

Low back pain and osteoarthritis pain: a perspective of estrogen.

Low back pain and osteoarthritis pain: a perspective of estrogen.

Low back pain (LBP) is the world's leading cause of disability and is increasing in prevalence more rapidly than any other pain condition. Intervertebral disc (IVD) degeneration and facet joint osteoarthritis (FJOA) are two common causes of LBP, and both occur more frequently in elderly women than in other populations. Moreover, osteoarthritis (OA) and OA pain, regardless of the joint, are experienced by up to twice as many women as men, and this difference is amplified during menopause. Changes in estrogen may be an important contributor to these pain states. Receptors for estrogen have been found within IVD tissue and nearby joints, highlighting the potential roles of estrogen within and surrounding the IVDs and joints. In addition, estrogen supplementation has been shown to be effective at ameliorating IVD degeneration and OA progression, indicating its potential use as a therapeutic agent for people with LBP and OA pain. This review comprehensively examines the relationship between estrogen and these pain conditions by summarizing recent preclinical and clinical findings. The potential molecular mechanisms by which estrogen may relieve LBP associated with IVD degeneration and FJOA and OA pain are discussed.

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来源期刊
Bone Research
Bone Research CELL & TISSUE ENGINEERING-
CiteScore
20.00
自引率
4.70%
发文量
289
审稿时长
20 weeks
期刊介绍: Established in 2013, Bone Research is a newly-founded English-language periodical that centers on the basic and clinical facets of bone biology, pathophysiology, and regeneration. It is dedicated to championing key findings emerging from both basic investigations and clinical research concerning bone-related topics. The journal's objective is to globally disseminate research in bone-related physiology, pathology, diseases, and treatment, contributing to the advancement of knowledge in this field.
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