Special issue for biology of the cell “intracellular trafficking of viruses”

In this special issue of Biology of the Cell, https:// onlinelibrary.wiley.com/doi/toc/10.1111/(ISSN)1768322X.viruses the authors explored the literature, describing how viruses exploit various host machineries to enter, replicate and exit from cells. The review by Gerber-Tichet & Kremer describes the variability in human adenoviruses immune response which is important for the design of virus-based vaccines. Focusing on skin cells, they outline the role of various adenovirus receptors for efficient infection of immune cells. They also highlight the importance of post-translational modifications of cell surface proteins in virus uptake (Gerber-Tichet Dienst & Kremer, 2022). Because virusreceptor interactions and subsequent viral fusion with host membrane cells are highly dynamic processes, advanced imaging tools are needed to shed light on virus entry. S. Padilla-Parra reviewed key microscopy approaches to study these steps in the context of HIV1 entry and fusion, including single particle tracking and spectral imaging (Padilla-Parra, 2023). The actin cytoskeleton plays a pivotal role during virus entry, but also exit from cells. The review by Serrano et al. describes how HIV-1 remodels the actin cytoskeleton during virus-receptor interactions, and proposes a model for the role of the actin cytoskeleton in HIV-1 assembly, budding, and release (Serrano et al., 2023). Viruses have evolved numerous strategies to travel within the cell from compartment-to-compartment. The review by Prasad & Bartenschlager describes how SARS-CoV-2 impacts intracellular trafficking pathways, including the hijacking of endosomal transport, modulation of ER/Golgi/endosomes membrane contact sites, inhibition of cellular mRNA nuclear export, perturba-