多参数磁共振成像和磁共振弹性成像评估减肥手术对非酒精性脂肪性肝病的早期影响。

IF 3.3 Q2 ENGINEERING, BIOMEDICAL
Hong Chang Tan, Elizabeth Shumbayawonda, Cayden Beyer, Lionel Tim-Ee Cheng, Albert Low, Chin Hong Lim, Alvin Eng, Weng Hoong Chan, Phong Ching Lee, Mei Fang Tay, Stella Kin, Jason Pik Eu Chang, Yong Mong Bee, George Boon Bee Goh
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引用次数: 0

摘要

背景:减肥手术是治疗病态肥胖最有效的方法,并能长期降低非酒精性脂肪性肝病(NAFLD)的严重程度。在减肥手术后的早期阶段,减肥手术对肝脏脂肪、炎症和纤维化的影响尚不清楚。目的:本探索性研究利用先进的成像方法研究减肥手术后早期代谢过渡期NAFLD和纤维化的变化。方法:9例病态肥胖患者行袖式胃切除术。在基线、术后即刻(1个月)和后期(6个月)分别进行多参数MRI (mpMRI)和磁共振弹性成像(MRE)检查。使用质子密度脂肪分数(PDFF)测量肝脏脂肪,使用铁校正T1 (cT1)测量疾病活动性,使用MRE测量肝脏硬度。采用重复测量方差分析评估纵向变化,采用Dunnett法进行多重比较。结果:所有参与者(年龄45.1±9.0岁,BMI 39.7±5.3 kg/m2)在基线时肝脏脂肪变性升高(PDFF >5%)。术后即刻PDFF由14.1±7.4%降至8.9±4.4% (p = 0.016), cT1由826.9±80.6 ms降至768.4±50.9 ms (p = 0.047)。这些改善持续到手术后期。减肥手术没有降低肝脏硬度测量值。结论:我们的研究结果支持使用MRI作为一种无创工具来监测减肥手术后早期病态肥胖患者的NAFLD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease.

Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease.

Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease.

Background: Bariatric surgery is the most effective treatment for morbid obesity and reduces the severity of nonalcoholic fatty liver disease (NAFLD) in the long term. Less is known about the effects of bariatric surgery on liver fat, inflammation, and fibrosis during the early stages following bariatric surgery.

Aims: This exploratory study utilises advanced imaging methods to investigate NAFLD and fibrosis changes during the early metabolic transitional period following bariatric surgery.

Methods: Nine participants with morbid obesity underwent sleeve gastrectomy. Multiparametric MRI (mpMRI) and magnetic resonance elastography (MRE) were performed at baseline, during the immediate (1 month), and late (6 months) postsurgery period. Liver fat was measured using proton density fat fraction (PDFF), disease activity using iron-correct T1 (cT1), and liver stiffness using MRE. Repeated measured ANOVA was used to assess longitudinal changes and Dunnett's method for multiple comparisons.

Results: All participants (Age 45.1 ± 9.0 years, BMI 39.7 ± 5.3 kg/m2) had elevated hepatic steatosis at baseline (PDFF >5%). In the immediate postsurgery period, PDFF decreased significantly from 14.1 ± 7.4% to 8.9 ± 4.4% (p = 0.016) and cT1 from 826.9 ± 80.6 ms to 768.4 ± 50.9 ms (p = 0.047). These improvements continued to the later postsurgery period. Bariatric surgery did not reduce liver stiffness measurements.

Conclusion: Our findings support using MRI as a noninvasive tool to monitor NAFLD in patient with morbid obesity during the early stages following bariatric surgery.

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来源期刊
CiteScore
12.00
自引率
0.00%
发文量
11
审稿时长
20 weeks
期刊介绍: The International Journal of Biomedical Imaging is managed by a board of editors comprising internationally renowned active researchers. The journal is freely accessible online and also offered for purchase in print format. It employs a web-based review system to ensure swift turnaround times while maintaining high standards. In addition to regular issues, special issues are organized by guest editors. The subject areas covered include (but are not limited to): Digital radiography and tomosynthesis X-ray computed tomography (CT) Magnetic resonance imaging (MRI) Single photon emission computed tomography (SPECT) Positron emission tomography (PET) Ultrasound imaging Diffuse optical tomography, coherence, fluorescence, bioluminescence tomography, impedance tomography Neutron imaging for biomedical applications Magnetic and optical spectroscopy, and optical biopsy Optical, electron, scanning tunneling/atomic force microscopy Small animal imaging Functional, cellular, and molecular imaging Imaging assays for screening and molecular analysis Microarray image analysis and bioinformatics Emerging biomedical imaging techniques Imaging modality fusion Biomedical imaging instrumentation Biomedical image processing, pattern recognition, and analysis Biomedical image visualization, compression, transmission, and storage Imaging and modeling related to systems biology and systems biomedicine Applied mathematics, applied physics, and chemistry related to biomedical imaging Grid-enabling technology for biomedical imaging and informatics
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