极端嗜热动物嗜热热菌合成同型亚精胺的新代谢途径。

IF 0.8 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of General and Applied Microbiology Pub Date : 2023-11-15 Epub Date: 2023-08-02 DOI:10.2323/jgam.2023.07.005

Tairo Oshima

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引用次数: 1

摘要

在极端的嗜热菌中，同精亚精胺是由两种酶的作用合成的。由dhs基因编码的第一个酶(注释为脱氧hypusine合成酶基因)催化在NAD存在下由两分子agmatine合成中间产物1,9-二(胍)-5-氮杂壬烷(=N1, n11 -二(氨基)-同亚精胺)。speB基因编码的氨基丙基亚精胺酶(aminopropylagmatinase)催化中间化合物水解成同亚精胺，释放2分子尿素。

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A new metabolic pathway for sym-homospermidine synthesis in an extreme thermophile, Thermus thermophilus.

In an extreme thermophile, Thermus thermophilus, sym-homospermidine is synthesized by the actions of two enzymes. The first enzyme coded by dhs gene (annotated to be deoxyhypusine synthase gene) catalyzes synthesis of an intermediate, supposed to be 1,9-bis(guanidino)-5-aza-nonane (=N¹, N¹¹-bis(amidino)-sym-homospermidine), from two molecules of agmatine in the presence of NAD. The second enzyme (aminopropylagmatinase) coded by speB gene catalyzes hydrolysis of the intermediate compound to sym-homospermidine releasing two molecules of urea.

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来源期刊

Journal of General and Applied Microbiology 生物-生物工程与应用微生物

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JGAM is going to publish scientific reports containing novel and significant microbiological findings, which are mainly devoted to the following categories: Antibiotics and Secondary Metabolites; Biotechnology and Metabolic Engineering; Developmental Microbiology; Environmental Microbiology and Bioremediation; Enzymology; Eukaryotic Microbiology; Evolution and Phylogenetics; Genome Integrity and Plasticity; Microalgae and Photosynthesis; Microbiology for Food; Molecular Genetics; Physiology and Cell Surface; Synthetic and Systems Microbiology.