一例癌症远处转移的长期生存病例：立体定向放射治疗与免疫检查点阻断治疗肺转移后脑转移的潜逃效应。

IF 0.5 Q4 ONCOLOGY

International Cancer Conference Journal Pub Date : 2023-04-03 eCollection Date: 2023-07-01 DOI:10.1007/s13691-023-00606-w

Sawa Kono, Yaichiro Hashimoto, Yurie Shirai, Yasuhiro Kunihiro, Kenta Ohmatsu, Miki Kawanishi, Shigehiko Kuribayashi, Kumiko Karasawa

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引用次数: 0

摘要

癌症的脑转移是罕见的，预后很差。癌症脑转移没有标准的治疗方法；因此，通常提供姑息治疗。我们报告了一例接受局灶性立体定向放射治疗（总剂量 = 52 Gy，分八个部分给药）与免疫检查点阻断治疗肺转移，获得长期无病生存（> 4年）。据我们所知，尽管已经有一些关于膀胱癌症潜逃效应的报道，但之前没有关于脑转移患者的报道。到目前为止，显示出“潜逃效应”的脑转移继续保持完全消退。

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A long-term survival case of bladder cancer with distant metastases: abscopal effect of brain metastases after stereotactic radiotherapy with immune checkpoint blockade therapy to lung metastases.

Brain metastases from bladder cancer are rare, with a poor prognosis. There is no standard treatment for bladder cancer with brain metastases; thus, palliative therapy is generally provided. We report a case of abscopal effect in a single brain metastasis from bladder cancer in a patient treated with focal stereotactic radiotherapy (total dose = 52 Gy, administered in eight fractions) with immune checkpoint blockade therapy for lung metastases, who achieved long-term disease-free survival (> 4 years). To our knowledge, although there have been some reports on abscopal effects in bladder cancer, there are no previous reports on patients with brain metastases. To date, the brain metastasis, which showed an "abscopal effect," continues to maintain complete regression.

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来源期刊

International Cancer Conference Journal ONCOLOGY-

自引率

14.30%

发文量

期刊介绍： This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)