Luigino Dal Maso, Daniela Pierannunzio, Silvia Francisci, Angela De Paoli, Federica Toffolutti, Salvatore Vaccarella, Silvia Franceschi, Rossella Elisei, Ugo Fedeli
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引用次数: 0
摘要
目的：过去十年中，随着美国甲状腺协会指南的不断更新，美国甲状腺癌放射性碘（RAI）治疗的使用率有所下降。相比之下，欧洲国家缺乏基于人口的数据。本研究旨在评估意大利使用 RAI 的频率和长期趋势：方法：从意大利国家医院出院数据库中，按性别和年龄段评估了2001-2018年期间甲状腺癌诊断甲状腺全切除术后RAI治疗的比例：在整个研究期间，149419 例甲状腺全切术中有 58% 的患者在术后接受了 RAI 治疗。男性和年轻患者使用 RAI 的比例较高；2007 年达到峰值（女性为 64%，男性为 68%），此后有所下降（2018 年：女性为 46%，男性为 53%），在所有年龄段和地区都观察到类似的模式：全国数据显示，意大利 RAI 治疗的趋势与在美国观察到的趋势相当。意大利和其他国家一样，需要进一步监测 RAI 的使用情况，以评估国际指南对甲状腺癌实际临床管理的影响。
Trends in radioactive iodine treatment after total thyroidectomy in Italy, 2001-2018.
Objective: A decrease in the use of radioactive iodine (RAI) treatment for thyroid cancer has been described in the last decade in the US following subsequent updates of the American Thyroid Association guidelines. By contrast, population-based data from European countries are lacking. The study aims to assess the frequency and long-term trends in the use of RAI in Italy.
Methods: From the Italian national hospital discharge database, the proportion of RAI treatment after total thyroidectomy with thyroid cancer diagnosis has been assessed by sex and age class during 2001-2018.
Results: Throughout the whole study period, RAI was performed after 58% of 149,419 total thyroidectomies. The use of RAI was higher for men and younger patients; it peaked in 2007 (64% in women and 68% in men) and declined thereafter (2018: 46% in women and 53% in men), with a similar pattern observed across all ages and areas.
Conclusion: National data show that in Italy trends in RAI treatment paraleled those observed in the US. Further monitoring of the use of RAI is warranted in Italy, as elsewhere, to assess the impact of international guidelines on real-life clinical management of thyroid cancer.
期刊介绍：
The ''European Thyroid Journal'' publishes papers reporting original research in basic, translational and clinical thyroidology. Original contributions cover all aspects of the field, from molecular and cellular biology to immunology and biochemistry, from physiology to pathology, and from pediatric to adult thyroid diseases with a special focus on thyroid cancer. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research. The journal will further publish formal guidelines in the field, produced and endorsed by the European Thyroid Association.
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