游泳训练减少了1型糖尿病小鼠肺组织的炎症和凋亡变化。

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM
Journal of Diabetes and Metabolic Disorders Pub Date : 2023-04-08 eCollection Date: 2023-06-01 DOI:10.1007/s40200-023-01202-8
Nasim Azizi, Afshin Rahbarghazi, Fariba Mirzaei Bavil, Reza Rahbarghazi, Arshad Ghaffari-Nasab, Jafar Rezaie, Aref Delkhosh, Mahdi Ahmadi
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引用次数: 0

摘要

背景:尽管肺组织容易受到糖尿病的影响,但很少有关于高血糖和治疗方式对肺实质的有害影响的报道。在这里,在接受四周游泳计划的小鼠(DM1)的糖尿病肺组织中监测凋亡变化。方法:将小鼠随机分为对照组;控制 + 游泳(S);糖尿病组(D);和糖尿病 + 游泳(D + S) 每组(每组8只小鼠)。在D和D + S组,小鼠腹膜内接受50mg/kg链脲佐菌素(STZ)。14天后,进行为期四周的游泳运动。应用实时PCR分析il-1β、bcl-2、bax和胱天蛋白酶-3的表达。使用H&E染色进行组织学检查。结果:与非糖尿病小鼠相比,DM1显著上调il-1β、bax和胱天蛋白酶-3,下调bcl-2(p 结论:这些数据表明,游泳运动可以通过调节细胞凋亡和炎症反应来减少小鼠肺中DM1相关的病理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Swimming training reduced inflammation and apoptotic changes in pulmonary tissue in type 1 diabetic mice.

Background: Despite the vulnerability of pulmonary tissue to diabetic conditions, there are few reports related to the detrimental effects of hyperglycemia and therapeutic modalities on lung parenchyma. Here, the apoptotic changes were monitored in the diabetic pulmonary tissue of mice (DM1) subjected to a four‒week swimming plan.

Methods: The mice were randomly allocated into Control; Control + Swimming (S); Diabetic group (D); and Diabetic + Swimming (D + S) groups (each in 8 mice). In the D and D + S groups, mice received intraperitoneally 50 mg/kg of streptozotocin (STZ). After 14 days, swimming exercise was done for four weeks. The expression of il-1β, bcl-2, bax, and caspase-3 was investigated using real-time PCR analysis. A histological examination was performed using H&E staining.

Results: DM1 significantly upregulated il-1β, bax, and caspase-3, and down-regulated bcl-2 compared to the non-diabetic mice (p < 0.05). We noted that swimming exercises reversed the expression pattern of all genes in the diabetic mice and closed to basal levels (p < 0.05). Data indicated that swimming exercise could diminish emphysematous changes, and interstitial pneumonitis induced by STZ. Along with these changes, swimming exercise had protective effects to reduce the thickness of the inter-alveolar septum and mean alveolar area in diabetic mice.

Conclusion: These data demonstrated that swimming exercises could decrease DM1-related pathologies in mouse lungs by regulating apoptosis and inflammatory response.

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来源期刊
Journal of Diabetes and Metabolic Disorders
Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine
CiteScore
4.80
自引率
3.60%
发文量
210
期刊介绍: Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.
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