总司令：单核细胞集结部队防御曲霉菌病。

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2023-10-01 DOI:10.1016/j.coi.2023.102371

Keyi Wang , Vanessa Espinosa , Amariliz Rivera

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引用次数: 0

摘要

真菌感染对人类健康的有害影响在过去几十年中稳步增加。2022年10月，世界卫生组织发布了有史以来第一份真菌病原体优先名单，强调了人们对这一问题的认识提高，以及在这一领域进行更多研究的必要性。有四种不同的真菌病原体被确定为关键的优先群体，烟曲霉（Af）是唯一的霉菌。Af是一种常见的环境真菌，导致全球90%以上的侵袭性曲霉菌病病例。肺对Af的保护主要依赖于先天效应细胞，中性粒细胞和单核细胞发挥着重要作用。在这篇综述中，我们将总结我们目前对单核细胞如何帮助协调对Af的抗真菌防御的理解。

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Commander-in-chief: monocytes rally the troops for defense against aspergillosis

The detrimental impact of fungal infections to human health has steadily increased over the past decades. In October of 2022, the World Health Organization published the first ever fungal-pathogen priority list highlighting increased awareness of this problem, and the need for more research in this area. There were four distinct fungal pathogens identified as critical priority groups with Aspergillus fumigatus (Af) being the only mold. Af is a common environmental fungus responsible for over 90% of invasive aspergillosis cases worldwide. Pulmonary protection against Af is critically dependent on innate effector cells with essential roles played by neutrophils and monocytes. In this review, we will summarize our current understanding of how monocytes help orchestrate antifungal defense against Af.

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.