中国老年人身体虚弱与认知功能:日常生活限制活动与抑郁的中介作用。

IF 3.3 Q2 GERIATRICS & GERONTOLOGY
C Peng, J A Burr, Y Yuan, K L Lapane
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引用次数: 1

摘要

背景:身体虚弱和认知障碍在全球普遍存在,特别是在中国,中国正经历着前所未有的人口老龄化。目的:研究中国社区老年人身体虚弱与认知功能变化水平和速率之间的关系,并量化日常生活活动(ADL)限制和抑郁症状的中介作用。设计:纵向。研究对象:中国健康与退休纵向研究(2011-2018)。参与者:5431名年龄≥60岁且具有有效身体虚弱信息的符合条件的成年人。测量方法:身体虚弱、认知功能、ADL限制和抑郁症状分别通过虚弱表型、认知状态(情景记忆、执行功能和定向)电话访谈、六项日常任务的表现和八项流行病学研究中心抑郁量表进行评估。使用潜在增长曲线模型来解决这些问题。结果:与非体弱的成年人相比,体弱前(β = -0.06)和体弱(β = -0.13)的整体认知功能和情景记忆明显差(体弱前:β = -0.05;虚弱:β = -0.14),执行功能(虚弱前:β = -0.04,虚弱:β = -0.10)和定向(虚弱前:β = -0.06;脆弱:基线时β = -0.07);那些身体虚弱的人更有可能在整体认知功能(β = 0.12)和情景记忆(β = 0.08)方面经历更快的衰退。ADL限制(β = -0.07)和抑郁症状(β = -0.14)显着介导了身体虚弱与认知功能水平之间的关联,但不是其下降速度。结论:有助于维持认知功能的干预策略可能受益于身体虚弱的早期筛查和评估。对于体弱多病和体弱多病的中国老年人,旨在帮助改善或维持日常生活活动和减少抑郁症状的项目可能有助于提高认知能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Physical Frailty and Cognitive Function among Older Chinese Adults: The Mediating Roles of Activities of Daily Living Limitations and Depression.

Background: Physical frailty and cognitive impairment are prevalent globally, particularly in China, which is experiencing an unprecedented aging of its large population.

Objectives: Examine the association between physical frailty and the level and rate of change of cognitive function, globally and by domain, among community-dwelling Chinese older adults, and quantify the mediation effects from activities of daily living (ADL) limitations and depressive symptoms.

Design: Longitudinal.

Setting: China Health and Retirement Longitudinal Study (2011-2018).

Participants: 5,431 eligible adults aged ≥ 60 years with valid information on physical frailty.

Measurements: Physical frailty, cognitive function, ADL limitations, and depressive symptoms were respectively assessed by frailty phenotypes, the Telephone Interview for Cognitive Status (episodic memory, executive function, and orientation), performance in six daily tasks, and the eight-item Center for Epidemiological Studies Depression Scale. Latent growth curve models were used to address the objectives.

Results: Compared to adults who were non-frail, those who were pre-frail (β = -0.06) and frail (β = -0.13) reported significantly worse global cognitive function and episodic memory (pre-frail: β = -0.05; frail: β = -0.14), executive function (pre-frail: β = -0.04, frail: β = -0.10), and orientation (pre-frail: β = -0.06; frail: β = -0.07) at baseline; those who were frail were more likely to experience faster decline in global cognitive function (β = 0.12) and episodic memory (β = 0.08). ADL limitations (β = -0.07) and depressive symptoms (β = -0.14) significantly mediated the association between physical frailty and the level of cognitive function, but not its rate of decline.

Conclusions: Intervention strategies that help maintain cognitive function may benefit from early screening and assessment of physical frailty. For pre-frail and frail older Chinese adults, programs designed to help improve or maintain activities of daily living and reduce number of depressive symptoms may contribute to better cognitive performance.

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来源期刊
Journal of Frailty & Aging
Journal of Frailty & Aging GERIATRICS & GERONTOLOGY-
CiteScore
5.90
自引率
7.70%
发文量
54
期刊介绍: The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons.          The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).
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