云南Va种群23个Y-STR基因座的遗传分析

IF 1.2 4区 医学 Q2 ANTHROPOLOGY
Jing Yuan, Lei Huang, Yuan Yin, Xiufeng Zhang
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引用次数: 0

摘要

背景:y染色体短串联重复序列(Y-STR)多态性被广泛应用于法医DNA分析。然而,在Y-STR单倍型参考数据库中缺乏中国Va人群的相关信息。目的:建立云南猿猴种群的y染色体单倍型参考数据库,探讨其与其他地理相邻类群的亲缘关系。对象和方法:使用PowerPlex Y23试剂盒对368名云南省无亲缘关系的Va健康男性进行23个Y-STR基因座分型。利用YHRD的AMOVA工具和MEGA 6.0软件分析遗传多态性。结果:23个Y-STR基因座的基因多样性(GD)范围为0.3092 (DYS19) ~ 0.7868 (DYS385a/b)。单倍型分析得到204个不同的单倍型,其中144个是独特的。单倍型多样性(HD)和鉴别能力(DC)分别为0.9852和0.5543。通过与其他22个参考类群的比较,结果表明云南Va是从其他类群中分离出来的。结论:23个Y-STR基因座具有较高的多态性和信息性,为法医调查和群体遗传学研究提供了丰富的基础遗传信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic analysis of 23 Y-STR loci in the Va population from Yunnan Province, Southwest China.

Background: Y-chromosomal short tandem repeat (Y-STR) polymorphisms are widely used in forensic DNA analysis. However, there is a lack of information about the Chinese Va population in the Y-STR Haplotype Reference Database.

Aim: To establish the Y-chromosome Haplotype Reference Database of the Yunnan Va population and investigate the population genetic relationships with other geographically adjacent groups.

Subjects and methods: In total, 23 Y-STR loci were genotyped with the PowerPlex Y23 Kit in 368 unrelated healthy Va males from Yunnan Province, Southwest China. Genetic polymorphism was analysed using the YHRD's AMOVA tools and the MEGA 6.0 software.

Results: The gene diversity (GD) of the 23 Y-STR loci ranged from 0.3092 (DYS19) to 0.7868 (DYS385a/b). According to haplotype analysis, 204 different haplotypes were obtained, out of which 144 were unique. The haplotype diversity (HD) and discrimination capacity (DC) were 0.9852 and 0.5543, respectively. By comparing the Yunnan Va group with the other 22 referential groups, the results revealed that Yunnan Va was isolated from other groups.

Conclusions: The 23 Y-STR loci were highly polymorphic and informative in the Yunnan Va population, and the results enriched the basic genetic information for forensic investigation and population genetic studies.

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来源期刊
Annals of Human Biology
Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生
CiteScore
3.40
自引率
5.90%
发文量
46
审稿时长
1 months
期刊介绍: Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.
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