社区层面的产前酒精和烟草暴露模式对6岁儿童非临床样本大脑结构的影响:一项南非试点研究。

IF 3.8 4区 医学 Q1 Medicine
Acta Neuropsychiatrica Pub Date : 2024-04-01 Epub Date: 2023-01-26 DOI:10.1017/neu.2022.34
Kristina A Uban, Deborah Jonker, Kirsten A Donald, Stefanie C Bodison, Samantha J Brooks, Eric Kan, Babette Steigelmann, Annerine Roos, Andrew Marshall, Shana Adise, Letitia Butler-Kruger, Brigitte Melly, Katherine L Narr, Shantanu H Joshi, Hein J Odendaal, Elizabeth R Sowell, Dan J Stein
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引用次数: 0

摘要

目前的小型研究利用产前酒精和烟草暴露模式(PAE和PTE)的前瞻性数据收集来检查与6岁儿童大脑结构结果的相关性,并作为一个试点来确定描述非临床儿童样本中PAE和PTE社区水平模式的前瞻性数据的价值。妊娠期安全通道研究的参与者在他们的孩子~6岁时进行了接触,并完成了大脑结构磁共振成像,以检查存档的PAE和PTE数据(n=51名儿童-母亲二人组)。线性回归用于进行全脑结构分析,并进行错误发现率(FDR)校正,以检验:(a)PAE、PTE的主要影响及其相互作用;以及(b)反映PAE和PTE模式的数据的预测潜力(例如数量、频率和定时(QFT))。PAE、PTE及其与大脑结构测量的相互作用之间的关联表明,皮层和皮层下改变的独特特征在仅PAE、仅PTE及其相互作用之间是不同的。检查PAE和PTE模式(如QFT)之间相关性的分析能够显著检测到在这个小的非临床儿童样本中的大脑改变(在FDR校正后幸存下来)。这些发现支持了这样一种假设,即在一小群幼儿中,考虑QFT和共同暴露对于识别PAE和/或PTE后的大脑改变很重要。目前的结果表明,大脑结构的致畸结果在PAE、PTE或它们的共同暴露以及模式(QFT)或暴露方面有所不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between community-level patterns of prenatal alcohol and tobacco exposure on brain structure in a non-clinical sample of 6-year-old children: a South African pilot study.

The current small study utilised prospective data collection of patterns of prenatal alcohol and tobacco exposure (PAE and PTE) to examine associations with structural brain outcomes in 6-year-olds and served as a pilot to determine the value of prospective data describing community-level patterns of PAE and PTE in a non-clinical sample of children. Participants from the Safe Passage Study in pregnancy were approached when their child was ∼6 years old and completed structural brain magnetic resonance imaging to examine with archived PAE and PTE data (n = 51 children-mother dyads). Linear regression was used to conduct whole-brain structural analyses, with false-discovery rate (FDR) correction, to examine: (a) main effects of PAE, PTE and their interaction; and (b) predictive potential of data that reflect patterns of PAE and PTE (e.g. quantity, frequency and timing (QFT)). Associations between PAE, PTE and their interaction with brain structural measures demonstrated unique profiles of cortical and subcortical alterations that were distinct between PAE only, PTE only and their interactive effects. Analyses examining associations between patterns of PAE and PTE (e.g. QFT) were able to significantly detect brain alterations (that survived FDR correction) in this small non-clinical sample of children. These findings support the hypothesis that considering QFT and co-exposures is important for identifying brain alterations following PAE and/or PTE in a small group of young children. Current results demonstrate that teratogenic outcomes on brain structure differ as a function PAE, PTE or their co-exposures, as well as the pattern (QFT) or exposure.

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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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