犬科和猫科遗传性视网膜疾病模型

IF 7.8 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Simon M Petersen-Jones, András M Komáromy
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引用次数: 0

摘要

猫和狗自然发生的遗传性视网膜疾病(IRD)为人类IRD提供了丰富的潜在模型来源。在许多情况下,同源基因突变的物种之间的表型非常相似。猫和狗都有一个高敏锐度视网膜区域,即中央区,相当于人类的黄斑,该区域有紧密排列的光感受器和较高的视锥密度。这一点以及与人类相似的眼球大小意味着这些大型动物模型能提供啮齿类动物模型无法提供的信息。已建立的猫和狗模型包括勒伯先天性无视力症、视网膜色素变性(包括隐性、显性和 X 连锁型)、无色觉、贝斯特病、先天性静止性夜盲和其他突触功能障碍、RDH5 相关性视网膜病变和斯塔加特病。事实证明,这些模型中的一些对于开发基因增强疗法等转化疗法非常重要。编辑犬基因组的工作取得了进展,但这需要克服犬繁殖的特殊性所带来的挑战。猫科动物基因组编辑面临的挑战较少。我们可以预见,未来将通过基因组编辑产生特定的猫和狗 IRD 模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Canine and Feline Models of Inherited Retinal Diseases.

Naturally occurring inherited retinal diseases (IRDs) in cats and dogs provide a rich source of potential models for human IRDs. In many cases, the phenotypes between the species with mutations of the homologous genes are very similar. Both cats and dogs have a high-acuity retinal region, the area centralis, an equivalent to the human macula, with tightly packed photoreceptors and higher cone density. This and the similarity in globe size to that of humans means these large animal models provide information not obtainable from rodent models. The established cat and dog models include those for Leber congenital amaurosis, retinitis pigmentosa (including recessive, dominant, and X-linked forms), achromatopsia, Best disease, congenital stationary night blindness and other synaptic dysfunctions, RDH5-associated retinopathy, and Stargardt disease. Several of these models have proven to be important in the development of translational therapies such as gene-augmentation therapies. Advances have been made in editing the canine genome, which necessitated overcoming challenges presented by the specifics of canine reproduction. Feline genome editing presents fewer challenges. We can anticipate the generation of specific cat and dog IRD models by genome editing in the future.

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来源期刊
Cold Spring Harbor perspectives in medicine
Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
14.30
自引率
1.90%
发文量
44
审稿时长
4-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.
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