部分呼气一氧化氮(FeNO)能作为克里米亚-刚果出血热住院患者的临床指标吗?

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Japanese journal of infectious diseases Pub Date : 2023-07-24 Epub Date: 2023-03-31 DOI:10.7883/yoken.JJID.2022.470
Ferhan Kerget, Buğra Kerget
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引用次数: 0

摘要

克里米亚-刚果出血热(CCHF)是一种由感染病毒传播的人畜共患疾病,是流行地区发病率和死亡率的重要原因。这项前瞻性研究旨在建立呼气中一氧化氮(FeNO)含量与CCHF临床预后之间的关系。该研究包括85名参与者:2022年5月至8月对55名CCHF患者和30名健康对照进行了随访。入院时测量FeNO水平,轻度/中度CCHF患者的FeNO水平为7.6±3.3 ppb,重度CCHF患者为2.5±2.1 ppb,健康对照组为6.7±1.7 ppb。对照组和轻度/中度CCHF患者之间的FeNO水平没有统计学上的显著差异(P=0.09),而重度CCHF患者的FeNO含量低于对照组和中度/轻度CCHF患者(两者均<0.001)。FeNO测量可以为预测CCHF早期的临床病程和预后提供一种无创且易于应用的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Can Fractional Exhaled Nitric Oxide (FeNO) Serve as a Clinical Indicator for Patients Hospitalized with Crimean-Congo Hemorrhagic Fever?

Crimean-Congo hemorrhagic fever (CCHF), a zoonotic disease spread by infected viruses, can be a significant cause of morbidity and mortality in endemic areas. This prospective study aimed to establish the relationship between fractional exhaled nitric oxide (FeNO) levels and clinical prognosis of CCHF. The study included 85 participants: 55 patients followed up for CCHF from May to August 2022, and 30 healthy controls. FeNO levels were measured upon hospital admission and were 7.6 ± 3.3 parts per billion (ppb) in patients with mild/moderate CCHF, 2.5 ± 2.1 ppb in patients with severe CCHF, and 6.7 ± 1.7 ppb in the healthy control group. There was no statistically significant difference in FeNO levels between the control group and patients with mild/moderate CCHF (P = 0.09), whereas patients with severe CCHF had lower FeNO levels than those in the control group and patients with mild/moderate CCHF (P < 0.001 for both). FeNO measurement may offer a noninvasive and easily applied approach for predicting the clinical course and prognosis of CCHF in the early stages of the disease.

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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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