妊娠小于34周早产儿出生后甲状腺激素和甲状腺功能障碍的发展趋势。

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2023-08-01 DOI:10.1080/15513815.2023.2195520

Shaohong Chen, Xiaoyan Lu, Bicheng Yang, Jieru Wu, Hui Huang, Yang Zou, Wenyan Tang, Ping Xu, Yu Yang

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引用次数: 0

摘要

目的:分析早产儿甲状腺功能检查(TFT)的变化趋势，评估甲状腺功能障碍的发生频率，确定影响甲状腺功能的因素。方法:分析25 ~ 34周胎龄早产儿TFT检查结果及甲状腺功能障碍的危险因素。结果:共有535名婴儿被纳入本研究。甲状腺激素水平随胎龄和产后年龄的变化而变化，甲状腺功能障碍的总发生率为50.3%。31例(5.8%)患儿TSH升高延迟。早产儿短暂性甲状腺功能低下与低出生体重和GA显著相关。先天性甲状腺功能减退与低出生体重、5分钟Apgar评分和多巴胺使用显著相关。结论:早产儿甲状腺激素水平与妊娠和出生年龄有关，早产儿甲状腺功能障碍发生率高，与GA和出生体重呈负相关。

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Developmental Trends in Postnatal Thyroid Hormones and Thyroid Dysfunction in Preterm Infants Born at less than 34 weeks Gestation.

Objectives: To analyse the trends in thyroid function tests (TFT) in preterm infants, evaluate the frequency of thyroid dysfunction, and identify the factors that influence thyroid function.

Methods: The TFT results and risk factors for thyroid dysfunction in preterm infants with gestational ages (GA) between 25 and 34 weeks were analysed.

Results: In total, 535 infants were enrolled in this study. Thyroid hormone levels vary with gestational and postnatal age, and the total frequency of thyroid dysfunction is 50.3%. Thirty-one infants (5.8%) had delayed TSH elevation. Transient hypothyroxinaemia of prematurity remained significantly associated with both lower birth weight and GA. Congenital hypothyroidism was significantly associated with lower birth weight, 5 min Apgar score, and dopamine use.

Conclusions: Thyroid hormone levels in preterm infants are related to gestation and postnatal age, the frequency of thyroid dysfunction in premature infants is high, and is negatively correlated with GA and birth weight.

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.