什么是细胞类型以及如何定义它?

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2022-07-21 DOI:10.1016/j.cell.2022.06.031

Hongkui Zeng

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引用次数: 98

摘要

细胞类型是生物体的基本功能单位。细胞类型在多个水平上表现出不同的表型特性，这使得它们难以定义、分类和理解。本文以哺乳动物的大脑为例，概述了基于进化和发育的细胞类型的基本原理，讨论了表征和分类细胞类型的方法，并研究了它们对生物体功能的贡献。我提出了一个关于细胞类型的概念框架和知识库的路线图，这将使我们能够更深入地了解健康和患病条件下细胞功能的动态变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

What is a cell type and how to define it?

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What is a cell type and how to define it?

Cell types are the basic functional units of an organism. Cell types exhibit diverse phenotypic properties at multiple levels, making them challenging to define, categorize, and understand. This review provides an overview of the basic principles of cell types rooted in evolution and development and discusses approaches to characterize and classify cell types and investigate how they contribute to the organism's function, using the mammalian brain as a primary example. I propose a roadmap toward a conceptual framework and knowledge base of cell types that will enable a deeper understanding of the dynamic changes of cellular function under healthy and diseased conditions.

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.