实时图像和延时技术选择单个囊胚在辅助生殖周期中转移。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-06-01 DOI:10.1017/S0967199423000151

Romualdo Sciorio, Gerard Campos, Simone Palini, Domenico Baldini, Ronny Janssens

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引用次数: 2

摘要

辅助生殖周期的成功应该是在替换一个胚胎后实现健康的单胎活产。因此，选择标准和如何选择具有高着床潜力的最佳胚胎进行移植一直是胚胎学家最关键的问题之一。在这种情况下，形态学评价一直是历史上应用的方法。然而，这种做法依赖于有限数量的单次观测，并且与操作员的高可变性有关。最近，胚胎培养的一项重大创新是引入了一种具有集成延时监测的新型培养箱，使胚胎学家能够分析胚胎发育的动态事件，从受精到囊胚形成。这种新颖的做法正在迅速发展，并已在世界各地的许多试管婴儿诊所实施。因此，本综述的主要目的是说明延时技术在现代胚胎学实验室的好处。我们特别讨论了囊胚塌陷事件和囊胚形态评估，并分析了它们与胚胎活力和着床潜力的关系。

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Real-time image and time-lapse technology to select the single blastocyst to transfer in assisted reproductive cycles.

The success of an assisted reproduction cycle should be the achievement of a healthy singleton live birth following the replacement of one embryo. Therefore, one of the most critical points for embryologists has been the selection criteria and how to choose the best embryo to transfer with high implantation potential. In this vein, morphological evaluation has been historically the method applied. However, this practice relies on a limited number of single observations and is associated with high operator variability. Recently, a major innovation in embryo culture has been the introduction of a new type of incubator with integrated time-lapse monitoring, which enables the embryologist to analyze the dynamic events of embryo development, from fertilization to blastocyst formation. This novel practice is quickly growing and has been implemented in many IVF clinics worldwide. Therefore, the main aim of this review is to illustrate the benefits of time-lapse technology in a modern embryology laboratory. In particular, we discuss the blastocyst collapse(s) event and morphometric blastocyst assessment and analyse their association with embryo viability and implantation potential.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.