Yeşim Öztürk Bakar, Süleyman Demiryas, Ayşe Ceylan Kılınçarslan, Mehmet Demirci, Nuray Kepil, Murat Tuğberk Bakar, Zeynep Taner, Edip Tokuç, Muhuyedin Abdırahman Ziyad, İhsan Taşçı, Bekir Sami Kocazeybek, Hrisi Bahar Tokman
{"title":"[产肠毒素的脆弱拟杆菌和核梭杆菌肠道定植与结直肠癌的关系:结肠活检的病例对照研究]。","authors":"Yeşim Öztürk Bakar, Süleyman Demiryas, Ayşe Ceylan Kılınçarslan, Mehmet Demirci, Nuray Kepil, Murat Tuğberk Bakar, Zeynep Taner, Edip Tokuç, Muhuyedin Abdırahman Ziyad, İhsan Taşçı, Bekir Sami Kocazeybek, Hrisi Bahar Tokman","doi":"10.5578/mb.20239929","DOIUrl":null,"url":null,"abstract":"<p><p>In recent years, it has been shown that some bacteria may be associated with colorectal cancer (CRC). In this study, it was aimed to investigate the role of Fusobacterium nucleatum and enterotoxigenic Bacteroides fragilis (ETBF) in the etiology of CRC by comparing the amounts of these bacteria in colon biopsy tissues of patients with CRC and healthy individuals. The amounts of F.nucleatum and ETBF were determined by quantitative polymerase chain reaction (qPCR) in colon biopsy samples taken from 35 CRC and 35 healthy individuals, and the results were compared in the patient and control groups. The detection rate and amounts of F.nucleatum were found to be statistically significantly higher in tissues of female patients with CRC compared to male patients (p= 0.003, p= 0.013, respectively). There was no statistically significant difference between the tissues of female and male patients with CRC in terms of detection rate and amount of ETBF (p= 0.521, p= 0.515, respectively). It was found that in the 50-74 age group, the amount of ETBF was statistically significantly higher in women and men with CRC compared to the controls (p= 0.005, p= 0.047, respectively), while the amount of F.nucleatum was statistically significantly higher in female patients compared to controls. However, no difference was found between male patients and controls (p= 0.009, p= 0.083). It was determined that the detection rate and amount of F.nucleatum in the tissues of patients with CRC, regardless of age and gender, were not statistically different from the controls (p= 0.473, p= 0.995, respectively), however, the detection rate of ETBF and the amount of ETBF were found to be statistically significantly higher (p= 0.002, p= 0.004, respectively). It has been determined that ETBF can play a role in the etiology of CRC in both men and women, and F.nucleatum only in women, in the age range of 50-74 years, when routine screenings for CRC are performed.</p>","PeriodicalId":18509,"journal":{"name":"Mikrobiyoloji bulteni","volume":"57 3","pages":"353-364"},"PeriodicalIF":1.1000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The Relationship of Enterotoxigenic Bacteroides fragilis and Fusobacterium nucleatum Intestinal Colonization with Colorectal Cancer: A Case-Control Study Performed with Colon Biopsies].\",\"authors\":\"Yeşim Öztürk Bakar, Süleyman Demiryas, Ayşe Ceylan Kılınçarslan, Mehmet Demirci, Nuray Kepil, Murat Tuğberk Bakar, Zeynep Taner, Edip Tokuç, Muhuyedin Abdırahman Ziyad, İhsan Taşçı, Bekir Sami Kocazeybek, Hrisi Bahar Tokman\",\"doi\":\"10.5578/mb.20239929\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In recent years, it has been shown that some bacteria may be associated with colorectal cancer (CRC). In this study, it was aimed to investigate the role of Fusobacterium nucleatum and enterotoxigenic Bacteroides fragilis (ETBF) in the etiology of CRC by comparing the amounts of these bacteria in colon biopsy tissues of patients with CRC and healthy individuals. The amounts of F.nucleatum and ETBF were determined by quantitative polymerase chain reaction (qPCR) in colon biopsy samples taken from 35 CRC and 35 healthy individuals, and the results were compared in the patient and control groups. The detection rate and amounts of F.nucleatum were found to be statistically significantly higher in tissues of female patients with CRC compared to male patients (p= 0.003, p= 0.013, respectively). There was no statistically significant difference between the tissues of female and male patients with CRC in terms of detection rate and amount of ETBF (p= 0.521, p= 0.515, respectively). It was found that in the 50-74 age group, the amount of ETBF was statistically significantly higher in women and men with CRC compared to the controls (p= 0.005, p= 0.047, respectively), while the amount of F.nucleatum was statistically significantly higher in female patients compared to controls. However, no difference was found between male patients and controls (p= 0.009, p= 0.083). It was determined that the detection rate and amount of F.nucleatum in the tissues of patients with CRC, regardless of age and gender, were not statistically different from the controls (p= 0.473, p= 0.995, respectively), however, the detection rate of ETBF and the amount of ETBF were found to be statistically significantly higher (p= 0.002, p= 0.004, respectively). It has been determined that ETBF can play a role in the etiology of CRC in both men and women, and F.nucleatum only in women, in the age range of 50-74 years, when routine screenings for CRC are performed.</p>\",\"PeriodicalId\":18509,\"journal\":{\"name\":\"Mikrobiyoloji bulteni\",\"volume\":\"57 3\",\"pages\":\"353-364\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mikrobiyoloji bulteni\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5578/mb.20239929\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mikrobiyoloji bulteni","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5578/mb.20239929","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
[The Relationship of Enterotoxigenic Bacteroides fragilis and Fusobacterium nucleatum Intestinal Colonization with Colorectal Cancer: A Case-Control Study Performed with Colon Biopsies].
In recent years, it has been shown that some bacteria may be associated with colorectal cancer (CRC). In this study, it was aimed to investigate the role of Fusobacterium nucleatum and enterotoxigenic Bacteroides fragilis (ETBF) in the etiology of CRC by comparing the amounts of these bacteria in colon biopsy tissues of patients with CRC and healthy individuals. The amounts of F.nucleatum and ETBF were determined by quantitative polymerase chain reaction (qPCR) in colon biopsy samples taken from 35 CRC and 35 healthy individuals, and the results were compared in the patient and control groups. The detection rate and amounts of F.nucleatum were found to be statistically significantly higher in tissues of female patients with CRC compared to male patients (p= 0.003, p= 0.013, respectively). There was no statistically significant difference between the tissues of female and male patients with CRC in terms of detection rate and amount of ETBF (p= 0.521, p= 0.515, respectively). It was found that in the 50-74 age group, the amount of ETBF was statistically significantly higher in women and men with CRC compared to the controls (p= 0.005, p= 0.047, respectively), while the amount of F.nucleatum was statistically significantly higher in female patients compared to controls. However, no difference was found between male patients and controls (p= 0.009, p= 0.083). It was determined that the detection rate and amount of F.nucleatum in the tissues of patients with CRC, regardless of age and gender, were not statistically different from the controls (p= 0.473, p= 0.995, respectively), however, the detection rate of ETBF and the amount of ETBF were found to be statistically significantly higher (p= 0.002, p= 0.004, respectively). It has been determined that ETBF can play a role in the etiology of CRC in both men and women, and F.nucleatum only in women, in the age range of 50-74 years, when routine screenings for CRC are performed.
期刊介绍：
Bulletin of Microbiology is the scientific official publication of Ankara Microbiology Society. It is published quarterly in January, April, July and October. The aim of Bulletin of Microbiology is to publish high quality scientific research articles on the subjects of medical and clinical microbiology. In addition, review articles, short communications and reports, case reports, editorials, letters to editor and other training-oriented scientific materials are also accepted. Publishing language is Turkish with a comprehensive English abstract. The editorial policy of the journal is based on independent, unbiased, and double-blinded peer-review. Specialists of medical and/or clinical microbiology, infectious disease and public health, and clinicians and researchers who are training and interesting with those subjects, are the target groups of Bulletin of Microbiology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
