辐射损伤和基于肠道微生物群的治疗。

IF 13.6 1区生物学 Q1 CELL BIOLOGY

Protein & Cell Pub Date : 2024-02-01 DOI:10.1093/procel/pwad044

Weihong Wang, Bota Cui, Yongzhan Nie, Lijuan Sun, Faming Zhang

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引用次数: 0

摘要

暴露于医用辐射源或意外辐射都会造成不同程度的辐射损伤（RI）。辐射损伤是一种涉及人体多个部位和器官的常见疾病，但目前有效的治疗方法却很有限。越来越多的证据表明，肠道微生物群与各种辐射损伤的发生和预防密切相关。本文总结了 10 种常见的 RI 及其可能的机制。文章还强调了基于微生物群的 RI 治疗方法的变化和潜力，包括益生菌、代谢物和微生物群移植。此外，文章还提出了一个 5P 框架，以提供管理 RI 的综合策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Radiation injury and gut microbiota-based treatment.

The exposure to either medical sources or accidental radiation can cause varying degrees of radiation injury (RI). RI is a common disease involving multiple human body parts and organs, yet effective treatments are currently limited. Accumulating evidence suggests gut microbiota are closely associated with the development and prevention of various RI. This article summarizes 10 common types of RI and their possible mechanisms. It also highlights the changes and potential microbiota-based treatments for RI, including probiotics, metabolites, and microbiota transplantation. Additionally, a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.

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来源期刊

Protein & Cell CELL BIOLOGY-

CiteScore

24.00

自引率

0.90%

发文量

1029

审稿时长

6-12 weeks

期刊介绍： Protein & Cell is a monthly, peer-reviewed, open-access journal focusing on multidisciplinary aspects of biology and biomedicine, with a primary emphasis on protein and cell research. It publishes original research articles, reviews, and commentaries across various fields including biochemistry, biophysics, cell biology, genetics, immunology, microbiology, molecular biology, neuroscience, oncology, protein science, structural biology, and translational medicine. The journal also features content on research policies, funding trends in China, and serves as a platform for academic exchange among life science researchers.