立体定向放射治疗确诊或推定犬胶质瘤的疗效。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
Veterinary and comparative oncology Pub Date : 2023-12-01 Epub Date: 2023-07-09 DOI:10.1111/vco.12920
Erin Trageser, Tiffany Martin, Braden Burdekin, Cullen Hart, Del Leary, Susan LaRue, Mary-Keara Boss
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引用次数: 0

摘要

颅内胶质瘤是狗体内第二常见的脑肿瘤。放射治疗为这种肿瘤类型提供了一种微创治疗选择。早期关于使用非调制放射治疗的报道表明,患有神经胶质瘤的狗预后较差,中位生存时间在4到6个月之间;最近更多的文献使用立体定向放射治疗(SRT)表明,犬胶质瘤的预后可能更有希望,生存时间接近12个月。2010年至2020年间进行了一项单机构回顾性研究,调查了活检证实的胶质瘤或基于MRI特征推定诊断为颅内胶质瘤的狗接受SRT治疗的结果。其中包括23只客户拥有的狗。短头型犬的比例过高,共13只(57%)。SRT方案包括16 Gy单次分数(n = 1.4%)、18 Gy单次分数(n = 1.4%)、24 Gy 3次分数(n = 20.91%)或27 Gy 4次分数(n = 1.4%)。21只狗(91%)的临床症状在SRT后得到改善。中位总生存时间(MST)为349天(95% CI, 162-584)。中位疾病特异性生存时间为413天(95% CI, 217-717)。当SRT被纳入确诊或推定为颅内胶质瘤的狗的治疗计划时,中位生存时间约为12个月。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of stereotactic radiation therapy for the treatment of confirmed or presumed canine glioma.

Intracranial gliomas are the second most common brain tumour in dogs. Radiation therapy provides a minimally invasive treatment option for this tumour type. Earlier publications reporting on the use of non-modulated radiation therapy suggested a poor prognosis for dogs with glioma, with median survival times ranging between 4 and 6 months; more recent literature utilizing stereotactic radiation therapy (SRT) demonstrates that the prognosis for canine gliomas may be more promising, with survival times closer to 12 months. A single institution retrospective study was performed between 2010 and 2020 investigating the outcomes of dogs with biopsy-confirmed glioma or a presumptive diagnosis of intra-cranial glioma based on MRI characteristics that were treated with SRT. Twenty-three client-owned dogs were included. Brachycephalic breeds were overrepresented, totalling 13 dogs (57%). SRT protocols included 16 Gy single fraction (n = 1, 4%), 18 Gy single fraction (n = 1, 4%), 24 Gy in 3 daily fractions (n = 20, 91%), or 27 Gy in four daily fractions (n = 1, 4%). Twenty-one dogs (91%) had improvement of their presenting clinical signs following SRT. Median overall survival time (MST) was 349 days (95% CI, 162-584). Median disease specific survival time was 413 days (95% CI, 217-717). When SRT is incorporated into the management plan for dogs with confirmed or presumed intracranial glioma, a median survival time of approximately 12 months may be achievable.

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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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