NLR抵抗体和炎性小体的组装和结构。

IF 10.4 1区 生物学 Q1 BIOPHYSICS
Zehan Hu, Jijie Chai
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引用次数: 4

摘要

核苷酸结合蛋白和富含亮氨酸重复序列(NLR)蛋白是动物和植物细胞内重要的免疫受体。感知病原体来源或应激相关信号诱导NLR寡聚化形成多蛋白复合物,在动物中称为炎症小体或在植物中称为抗性小体,介导宿主免疫反应。在过去的几年中,我们对NLR生物学的理解取得了重大进展,特别是对这两种含NLR复合物的结构观点的理解。在本文中,我们回顾了NLR炎症小体和抵抗小体如何被激活和组装的结构知识的最新进展,以及结构信息如何提供对其独特作用机制的见解。还讨论了NLR炎症小体和抵抗小体的共性和差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assembly and Architecture of NLR Resistosomes and Inflammasomes.

Nucleotide-binding and leucine-rich repeat (NLR) proteins are critical intracellular immune receptors in both animals and plants. Perception of pathogen-derived or stress-associated signals induces NLR oligomerization to form multiprotein complexes called inflammasomes in animals or resistosomes in plants to mediate host immune response. Significant progress has been made during the past few years in our understanding of NLR biology, particularly the structural perspective of these two types of NLR-containing complexes. In this article, we review the latest advances in our structural knowledge of how NLR inflammasomes and resistosomes are activated and assembled and how the structural information provides insight into their distinct mechanisms of action. Commonalities and differences between NLR inflammasomes and resistosomes are also discussed.

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来源期刊
Annual Review of Biophysics
Annual Review of Biophysics 生物-生物物理
CiteScore
21.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Biophysics, in publication since 1972, covers significant developments in the field of biophysics, including macromolecular structure, function and dynamics, theoretical and computational biophysics, molecular biophysics of the cell, physical systems biology, membrane biophysics, biotechnology, nanotechnology, and emerging techniques.
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