{"title":"联合使用环孢素 A 和甲基强的松龙治疗小儿史蒂文斯-约翰逊综合征/毒性表皮坏死重叠综合征。","authors":"Shinta Trilaksmi Dewi, Laily Noor Qomariah, Widya Khairunisa Sarkowi, Monika Puspitasari, Miya Khalidah, Marcella Anggatama, Dwinanda Almira Rizkiani, Kristiana Etnawati, Sri Awalia Febriana","doi":"10.4081/dr.2023.9656","DOIUrl":null,"url":null,"abstract":"<p><p>The treatment of epidermal necrolysis in pediatric patients remains a major challenge. Cyclosporine A has emerged as a promising therapy for epidermal necrolysis in adults; however, its efficacy in children is unclear. We present the case of a boy with Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome who was initially resistant to methylprednisolone monotherapy but improved after receiving the combination of cyclosporine A and methylprednisolone. Published reports on the use of cyclosporine A for pediatric epidermal necrolysis are also briefly reviewed.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"15 2","pages":"9656"},"PeriodicalIF":2.3000,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/82/dr-15-2-9656.PMC10327664.pdf","citationCount":"0","resultStr":"{\"title\":\"Combination of cyclosporine A and methylprednisolone to treat pediatric Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome.\",\"authors\":\"Shinta Trilaksmi Dewi, Laily Noor Qomariah, Widya Khairunisa Sarkowi, Monika Puspitasari, Miya Khalidah, Marcella Anggatama, Dwinanda Almira Rizkiani, Kristiana Etnawati, Sri Awalia Febriana\",\"doi\":\"10.4081/dr.2023.9656\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The treatment of epidermal necrolysis in pediatric patients remains a major challenge. Cyclosporine A has emerged as a promising therapy for epidermal necrolysis in adults; however, its efficacy in children is unclear. We present the case of a boy with Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome who was initially resistant to methylprednisolone monotherapy but improved after receiving the combination of cyclosporine A and methylprednisolone. Published reports on the use of cyclosporine A for pediatric epidermal necrolysis are also briefly reviewed.</p>\",\"PeriodicalId\":11049,\"journal\":{\"name\":\"Dermatology Reports\",\"volume\":\"15 2\",\"pages\":\"9656\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2023-06-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/82/dr-15-2-9656.PMC10327664.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatology Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4081/dr.2023.9656\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/6/7 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatology Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4081/dr.2023.9656","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/6/7 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
治疗儿童表皮坏死症仍是一项重大挑战。环孢素 A 已成为治疗成人表皮坏死症的有效药物，但其对儿童的疗效尚不明确。我们介绍了一例患有史蒂文斯-约翰逊综合征/毒性表皮坏死症重叠综合征的男孩，他最初对甲基强的松龙单药治疗产生耐药性，但在接受环孢素 A 和甲基强的松龙联合治疗后病情有所好转。本文还简要回顾了已发表的关于使用环孢素 A 治疗小儿表皮坏死症的报告。
Combination of cyclosporine A and methylprednisolone to treat pediatric Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome.
The treatment of epidermal necrolysis in pediatric patients remains a major challenge. Cyclosporine A has emerged as a promising therapy for epidermal necrolysis in adults; however, its efficacy in children is unclear. We present the case of a boy with Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome who was initially resistant to methylprednisolone monotherapy but improved after receiving the combination of cyclosporine A and methylprednisolone. Published reports on the use of cyclosporine A for pediatric epidermal necrolysis are also briefly reviewed.
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