组织化学和细胞化学中的组蛋白修饰。

IF 1.6 4区 生物学 Q4 CELL BIOLOGY
Riko Kitazawa, Ryuma Haraguchi, Sohei Kitazawa
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引用次数: 0

摘要

在细胞分裂过程中,保持染色质处于稳定状态对于基因组稳定、转录、复制、DNA修复以及精确可靠的染色体分离和端粒维持至关重要。在过去的十年中,染色质重塑的研究取得了很大的进展,其中组蛋白的修饰是参与许多基本细胞过程的关键因素。病理学家常规检查的肿瘤细胞的核发现只不过是基因组和组蛋白改变的反映。此外,已知组蛋白功能受损与糖尿病和动脉粥样硬化等常见疾病有关,因此被认为是潜在的治疗靶点。本文首先概述了组蛋白的生理功能,其次阐述了组蛋白对病理状态的改变,强调了免疫组化在组织病理诊断中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Histone Modification in Histochemistry and Cytochemistry.

Histone Modification in Histochemistry and Cytochemistry.

Histone Modification in Histochemistry and Cytochemistry.

Histone Modification in Histochemistry and Cytochemistry.

Keeping chromatin in a stable state is essential for genome stability, scheduled transcription, replication, DNA repair, and precise and reliable chromosome segregation and telomere maintenance during cell division. Over the past decade, research on chromatin remodeling has made great strides whereby modification of histone proteins is a key factor involved in many of the essential cellular processes. The nuclear findings of tumor cells that pathologists routinely examine are nothing but reflections of both genomic and histone alterations. Moreover, impaired histone function is known to be related to common diseases such as diabetes and atherosclerosis, and is, therefore, considered a potential therapeutic target. The present review first outlines the physiological function of histone proteins, and second, demonstrates their alterations to pathological states, emphasizing the importance of immunohistochemistry in histopathological diagnosis.

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来源期刊
Acta Histochemica Et Cytochemica
Acta Histochemica Et Cytochemica 生物-细胞生物学
CiteScore
3.50
自引率
8.30%
发文量
17
审稿时长
>12 weeks
期刊介绍: Acta Histochemica et Cytochemica is the official online journal of the Japan Society of Histochemistry and Cytochemistry. It is intended primarily for rapid publication of concise, original articles in the fields of histochemistry and cytochemistry. Manuscripts oriented towards methodological subjects that contain significant technical advances in these fields are also welcome. Manuscripts in English are accepted from investigators in any country, whether or not they are members of the Japan Society of Histochemistry and Cytochemistry. Manuscripts should be original work that has not been previously published and is not being considered for publication elsewhere, with the exception of abstracts. Manuscripts with essentially the same content as a paper that has been published or accepted, or is under consideration for publication, will not be considered. All submitted papers will be peer-reviewed by at least two referees selected by an appropriate Associate Editor. Acceptance is based on scientific significance, originality, and clarity. When required, a revised manuscript should be submitted within 3 months, otherwise it will be considered to be a new submission. The Editor-in-Chief will make all final decisions regarding acceptance.
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