Orexin受体拮抗剂在睡眠障碍和癫痫的病理生理学和治疗中的作用

IF 2.5 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Mohammad Sheibani , Maryam Shayan , Mina Khalilzadeh , Mehdi Ghasemi , Ahmad Reza Dehpour
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引用次数: 6

摘要

过去几十年来,科学家们一直在争论睡眠与癫痫之间的相关性。尽管睡眠和癫痫之间的相似性和对比性已经被考虑过,但它们相互交织的本质直到19世纪才被揭示出来。睡眠被认为是一种通过交替的脑电活动反复出现的身心状态。有文献表明,睡眠障碍与癫痫有关。癫痫发作的起源、抑制和传播都受到睡眠的影响。因此,在癫痫患者中,睡眠障碍是一种常见的合并症。同时,食欲素,一种促进觉醒的神经肽,对睡眠和癫痫都有双向作用。食欲素及其同源受体,食欲素受体1型(OX1R)和2型(OX2R),通过激活各种下游信号通路来协调其作用。尽管食欲素在被发现后不久就被认为是失眠的治疗靶点,但其对精神疾病和癫痫发作的潜在作用已在临床前研究中得到证实。这篇综述旨在讨论睡眠、癫痫和食欲素之间的关系是否明显是相互的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Orexin receptor antagonists in the pathophysiology and treatment of sleep disorders and epilepsy

Orexin receptor antagonists in the pathophysiology and treatment of sleep disorders and epilepsy

The correlation between sleep and epilepsy has been argued over the past decades among scientists. Although the similarities and contrasts between sleep and epilepsy had been considered, their intertwined nature was not revealed until the nineteenth century. Sleep is recognized as a recurring state of mind and body through alternating brain electrical activities. It is documented that sleep disorders are associated with epilepsy. The origin, suppression, and spread of seizures are affected by sleep. As such, in patients with epilepsy, sleep disorders are a frequent comorbidity. Meanwhile, orexin, a wake-promoting neuropeptide, provides a bidirectional effect on both sleep and epilepsy. Orexin and its cognate receptors, orexin receptor type 1 (OX1R) and type 2 (OX2R), orchestrate their effects by activating various downstream signaling pathways. Although orexin was considered a therapeutic target in insomnia shortly after its discovery, its potential usefulness for psychiatric disorders and epileptic seizures has been suggested in the pre-clinical studies. This review aimed to discuss whether the relationship between sleep, epilepsy, and orexin is clearly reciprocal.

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来源期刊
Neuropeptides
Neuropeptides 医学-内分泌学与代谢
CiteScore
5.40
自引率
6.90%
发文量
55
审稿时长
>12 weeks
期刊介绍: The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.
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